Analyses of the potential oxygen transfer capability in placentae from infants succumbing to sudden infant death syndrome
| Autor: | Paul Sibbons, Colin J. Green, D Condell, John Gillan, Tahera Ansari |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Oxygen transfer Birth weight Placenta Physiology Gestational Age Sudden death Oxygen Consumption Pregnancy medicine Humans Maternal-Fetal Exchange reproductive and urinary physiology Fetus business.industry Infant Newborn Obstetrics and Gynecology Apnea Sudden infant death syndrome medicine.disease Oxygen medicine.anatomical_structure embryonic structures Pediatrics Perinatology and Child Health Infant Small for Gestational Age Small for gestational age Female medicine.symptom business Sudden Infant Death |
| Zdroj: | Early human development. 76(2) |
| ISSN: | 0378-3782 |
| Popis: | Background : Morphometric oxygen diffusive conductance ( D p ) was estimated to assess the potential efficiency of oxygen transfer across the materno–fetal interface in placentae obtained from victims of sudden infant death syndrome (SIDS). Study design : SIDS placentae were retrieved from archived storage and classified into normal birth weight (NBW, n =16), or small for gestational age (SGA, n =9) and compared against control placentae ( n =40) or SGA ( n =24) placentae. A combination of stereological techniques and physiological constants were used to estimate total D p . Results : SIDS NBW cases showed a crucial reduction in fetal capillary surface area when compared with control placentae. SIDS SGA showed a number of deficiencies in basic volumetric and surface area parameters. Values for total and specific D p in placentae in both SIDS groups were maintained at levels comparable with control and SGA cases, respectively. Conclusion : Since more reductions were observed in SIDS SGA group, this suggests that factors responsible for these reductions maybe associated with SGA rather than being SIDS-specific factors. |
| Databáze: | OpenAIRE |
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