Siloxane-poly(lactic acid)-vaterite composites with 3D cotton-like structure
| Autor: | Toshihiro Kasuga, Kazuya Oribe, Yoshio Ota, Hirotaka Maeda, Akiko Obata, Xianfeng Yao |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Siloxanes Polymers Surface Properties Polyesters Biomedical Engineering Biophysics chemistry.chemical_element Bioengineering Calcium Biomaterials Mice chemistry.chemical_compound Vaterite Animals Lactic Acid Composite material Molecular Structure 3T3 Cells Silicate Electrospinning Lactic acid Polyester Calcium carbonate Microscopy Fluorescence chemistry Siloxane Microscopy Electron Scanning |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 23:2349-2357 |
| ISSN: | 1573-4838 0957-4530 |
| DOI: | 10.1007/s10856-012-4607-5 |
| Popis: | Trace amounts of ionic calcium and silicon species have been reported to stimulate the proliferation, differentiation, and mineralization of bone-forming cells. Composite materials comprising siloxane-doped calcium carbonate (vaterite) particles and poly(L-lactic acid) have been developed [siloxane-poly(lactic acid)-vaterite hybrid-composite, SiPVH] so far; they were designed such that calcium and silicate ions are gradually released from SiPVH and they show the chronic effects of ions on cellular activities. In the present work, SiPVH with a 3D cotton-like structure was prepared by electrospinning to obtain the major advantages of excellent bioactivity and ease of handling for bone filling surgery. The diameter of the fibrous skeletons that form structure of the cotton-like SiPVH was controlled to ~10 μm to achieve cellular migration into the spaces between fibers. The resulting cotton-like SiPVH showed good flexibility. The fiber surface was coated rapidly with numerous particles of several hundred nanometers in size by alternate soaking in CaCl(2) and Na(2)HPO(4). The treated cotton-like material, which released calcium and silicate ions gradually, showed good cellular migration behavior into the 3D structure in cell culture tests using murine osteoblast-like MC3T3-E1 cells. |
| Databáze: | OpenAIRE |
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