Hydration and Dynamic Behavior of Cyclodextrins in Aqueous Solution
| Autor: | Toshiyuki Shikata, Rintaro Takahashi, Yuichi Satokawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Cyclodextrins
Range (particle radiation) Aqueous solution Hydrogen bond Chemistry Spectrum Analysis Water Chemical modification Dielectric Spectral line Surfaces Coatings and Films Solutions Models Chemical Computational chemistry Electrochemistry Materials Chemistry Thermodynamics Relaxation (physics) Molecule Physical chemistry Physical and Theoretical Chemistry |
| Zdroj: | The Journal of Physical Chemistry B. 111:12239-12247 |
| ISSN: | 1520-5207 1520-6106 |
| DOI: | 10.1021/jp0751864 |
| Popis: | The hydration state and dynamics of plain and chemically modified cyclodextrins (CDs) in aqueous solution were investigated by using dielectric relaxation measurements at 25 degrees C over a wide frequency range up to 20 GHz, which is the relaxation frequency of pure liquid water molecules. The obtained dielectric relaxation spectra were decomposed into two major and one minor relaxation modes with relaxation times of approximately 8.3, 20-25, and 1000-2500 ps, respectively, depending on the CD species. The two major modes, fast and medium, were attributed to a rotational relaxation process of water molecules belonging to the bulk (free) state and an exchange of water molecules hydrated to CDs owing to hydrogen bond formation. The hydration numbers of the CDs strongly depend on the number of hydroxy (OH) groups controlled by chemical modification such as methylation. Increasing the number of methoxy or 2-hydroxypropoxy groups increases the hydration number of CD molecules, and results in higher solubilities of the chemically modified CDs than those of the plain CDs. The minor, slow mode was assigned to overall rotational relaxation for CDs with finite permanent dipole moments, which also depends on the number of OH groups. |
| Databáze: | OpenAIRE |
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