Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in 'real-world' settings
Autor: | Graham Pawelec, Nan-ping Weng |
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Rok vydání: | 2021 |
Předmět: |
Longevity of vaccine response
2019-20 coronavirus outbreak medicine.medical_specialty Aging Coronavirus disease 2019 (COVID-19) business.industry SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Public health Immunology Adoptive immunotherapy Vaccination RC952-954.6 COVID-19 RC581-607 Older population Neutralizing mAb Immunity Geriatrics medicine Commentary Immunologic diseases. Allergy Intensive care medicine business |
Zdroj: | Immunity & Ageing : I & A Immunity & Ageing, Vol 18, Iss 1, Pp 1-4 (2021) |
ISSN: | 1742-4933 |
Popis: | The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2 vaccines in older adults has been very encouraging but the longevity of vaccine immunity is currently unknown and protection against emerging variants may be lower. Adoptive immunotherapy with neutralizing mAb may offer an alternative for poor vaccine responders, while the mechanisms underlying failure to respond are still unclear. Further studies of B and T cell responses and their regulation particularly in older populations will provide a more solid foundation to develop suitable approaches to optimize vaccine responses of older adults who fail to mount a durable response. |
Databáze: | OpenAIRE |
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