Hypertension-enhanced monocyte adhesion in experimental atherosclerosis
| Autor: | Richard K. Sibley, Christopher K. Zarins, Philip S. Tsao, Bradford I. Tropea, Phil Huie, John P. Cooke |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Pathology Endothelium Arteriosclerosis Macrophage-1 Antigen Vascular Cell Adhesion Molecule-1 Aorta Thoracic Blood Pressure Aortic Coarctation Monocytes medicine.artery Cell Adhesion medicine Animals Thoracic aorta Aorta Factor VIII Vascular disease Cell adhesion molecule business.industry Macrophages Monocyte Aortic Valve Stenosis medicine.disease Immunohistochemistry Surgery Stenosis Blood pressure medicine.anatomical_structure Gene Expression Regulation Microscopy Fluorescence Hypertension cardiovascular system Diet Atherogenic Endothelium Vascular Rabbits Tunica Intima Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Vascular Surgery. 23:596-605 |
| ISSN: | 0741-5214 |
| DOI: | 10.1016/s0741-5214(96)80038-3 |
| Popis: | Purpose: Hypertension is a known clinical risk factor for atherosclerosis. In experimental atherosclerosis, monocyte adhesion to the endothelial surface is enhanced and is considered to be an important early stage in plaque formation. We tested the hypothesis that hypertension enhances monocyte adhesion in experimental atherosclerosis.Methods: Twenty-two New Zealand White rabbits were fed an atherogenic diet for 3 weeks to induce plaque formation. Aortic coarctation was created in eight rabbits by wrapping a Dacron band around the midportion of the descending thoracic aorta (stenosis group), whereas six rabbits underwent banding without aortic constriction (no stenosis group). Eight rabbits served as nonoperated controls. Monocyte binding to the aortic endothelial surface was counted with epifluorescent microscopy on standard aortic segments proximal and distal to the band. Immunohistochemistry was performed for the following antibodies: VCAM-1, RAM11, CD11b, and factor VIII.Results: Mean blood ressure was 89±3 mm Hg in the aorta proximal to the stenosis, compared with 64±4 mm Hg in the no stenosis group and 74±3 mm Hg in the control group (p |
| Databáze: | OpenAIRE |
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