Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study
Autor: | Maarit Niinimäki, Tapani Ebeling, Paula Pesonen, Tuija Männistö, Juha Auvinen, Susanna M. Savukoski, Eila T J Suvanto, Katri Puukka |
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Rok vydání: | 2021 |
Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases General Mathematics Thyrotropin Autoimmunity Hypothyroidism Thyroid peroxidase Internal medicine Humans Medicine Subclinical infection biology business.industry Applied Mathematics Thyroid Obstetrics and Gynecology Middle Aged medicine.disease Thyroid Diseases Anti-thyroid autoantibodies Menopause Cross-Sectional Studies medicine.anatomical_structure biology.protein Female business Climacteric Hormone Cohort study |
Zdroj: | Menopause. 28:1053-1059 |
ISSN: | 1530-0374 |
DOI: | 10.1097/gme.0000000000001800 |
Popis: | We investigated whether more advanced climacteric stage in the mid-40s is associated with thyroid autoimmunity and dysfunction.This cross-sectional cohort study included 2,569 46-year-old women. Thyroid hormone, thyroid peroxidase antibodies, and follicle-stimulating hormone levels were determined. Using menstrual history and follicle-stimulating hormone levels, the participants were divided into climacteric (n = 340) and preclimacteric (n = 2,229) groups. Women diagnosed with premature ovarian insufficiency (menopause by 40 y of age) were excluded. The use of thyroid medication was evaluated from the medication reimbursement register. The prevalence of thyroid medication use, laboratory-based thyroid dysfunction, and thyroid peroxidase antibody positivity was compared between the two groups. The association between climacteric status and thyroid disorders was investigated using a logistic regression model including smoking and thyroid antibody status.At 46 years old, climacteric women used thyroid medication more often than preclimacteric women (9.1% vs 6.1%; P = 0.04). There was no difference in the prevalence of subclinical or clinical hypothyroidism and hyperthyroidism in nonmedicated participants (5.5% vs 5.0%; P = 0.7) or thyroid peroxidase antibody positivity (14.0% vs 15.0%, P = 0.7). In the regression model, being climacteric (OR = 1.6; 95% CI 1.1-2.3; P = 0.02) and antibody positivity (OR 4.9; 95% CI 3.6-6.6; P 0.001) were associated with a higher prevalence of thyroid dysfunction.More advanced climacteric stage in the mid-40s was slightly associated with thyroid dysfunction but not thyroid autoimmunity.Video Summary:http://links.lww.com/MENO/A771. |
Databáze: | OpenAIRE |
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