Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort
| Autor: | Lutz Frölich, Kaj Blennow, Karen Meersmans, Kristel Sleegers, Cristina Legido-Quigley, Mara ten Kate, Tommi Suvitaival, Julius Popp, Frederik Barkhof, Sarah Westwood, Tahmina Ahmad, Petra Proitsi, Jill C. Richardson, Magda Tsolaki, José Luis Molinuevo, Mikel Tainta, Alison L. Baird, Pablo Martinez-Lage, Philip Scheltens, Abdul Hye, Yvonne Freund-Levi, Lorena Rami, Adnan Ali, Stephanie J.B. Vos, Frans R.J. Verhey, Stuart G. Snowden, Rik Vandenberghe, Valerija Dobricic, Charlotte E. Teunissen, Pieter Jelle Visser, Petronella Kettunen, Min Kim, Peter Johannsen, Régis Bordet, David J. Merkler, Nicholas J. Ashton, Alberto Lleó, Henrik Zetterberg, Gwendoline Peyratout, Alejo J. Nevado-Holgado, Anders Wallin, Sebastiaan Engelborghs, Olivier Blin, Johannes Streffer, Isabel Sala, Isabelle Bos, Simon Lovestone, Ellen De Roeck, Lars Bertram, Silvy Gabel, Giovanni B. Frisoni |
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| Přispěvatelé: | King‘s College London, University of Cambridge [UK] (CAM), Steno Diabetes Center of Copenhagen [Gentofte, Denmark], University of South Florida [Tampa] (USF), University of Oxford, Maastricht University [Maastricht], University Hospitals Leuven [Leuven], Amsterdam UMC - Amsterdam University Medical Center, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), University of Antwerp (UA), Troubles cognitifs vasculaires et dégénératifs, Université de Lille, Sciences et Technologies, CHU Lille, Hospital Clinic (IDIBAPS), University of Gothenburg (GU), AHEPA University General Hospital [Thessaloniki], Hospital de la Santa Creu i Sant Pau, Lausanne University Hospital, Center for Research and Advanced Therapies CITA-Alzheimer Foundation [San Sebastián], Copenhagen University Hospital, Karolinska University Hospital [Stockholm], Universität Heidelberg [Heidelberg] = Heidelberg University, Universität zu Lübeck = University of Lübeck [Lübeck], Université de Genève = University of Geneva (UNIGE), Geneva University Hospital (HUG), Sahlgrenska University Hospital [Gothenburg], UCL, Institute of Neurology [London], Janssen Pharmaceutica [Beerse], Universität Heidelberg [Heidelberg], Otten, Lisa, Clinical sciences, Neurology, Amsterdam Neuroscience - Neurodegeneration, Laboratory Medicine, Radiology and nuclear medicine, Psychiatrie & Neuropsychologie, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, MUMC+: MA Med Staf Spec Psychiatrie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Male Neurology Epidemiology Neuropsychological Tests Hippocampus RECOMMENDATIONS Cohort Studies ddc:616.89 0302 clinical medicine Cerebrospinal fluid MARKERS Biomarker discovery Brain volume measurements Medicine(all) OLEAMIDE biology medicine.diagnostic_test Health Policy Brain INDUCED LIPOKINE EMIF-AD Amyloidosis Middle Aged Alzheimer's disease Magnetic Resonance Imaging PERTURBATIONS 3. Good health Psychiatry and Mental health ACID Female Alzheimer’s disease Life Sciences & Biomedicine medicine.medical_specialty Amyloid Tau protein Clinical Neurology tau Proteins CSF METABOLISM Article Aged Amyloid beta-Peptides/blood Amyloid beta-Peptides/cerebrospinal fluid Amyloidosis/blood Amyloidosis/cerebrospinal fluid Amyloidosis/metabolism Biomarkers/blood Biomarkers/cerebrospinal fluid Brain/pathology Cognitive Dysfunction/diagnosis Hippocampus/metabolism Humans Memory/physiology Metabolomics tau Proteins/blood tau Proteins/cerebrospinal fluid Biomarkers Cognitive function measurements Dementia Tau 03 medical and health sciences Cellular and Molecular Neuroscience Developmental Neuroscience Memory Internal medicine 12 13-DIHOME medicine 13-DIHOME Cognitive Dysfunction BIOSYNTHESIS Biology Mini–Mental State Examination Amyloid beta-Peptides Science & Technology business.industry [SCCO.NEUR]Cognitive science/Neuroscience [SCCO.NEUR] Cognitive science/Neuroscience medicine.disease 030104 developmental biology ddc:618.97 biology.protein Human medicine Neurology (clinical) Neurosciences & Neurology Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & dementia, vol. 15, no. 6, pp. 817-827 Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, de Roeck, E, Sleegers, K, Bordet, R G, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's and Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004 Alzheimer's & Dementia : the Journal of the Alzheimer's Association Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩ Alzheimer's & Dementia Alzheimer's & Dementia, 2019, 15 (6), pp.817-827. ⟨10.1016/j.jalz.2019.03.004⟩ Alzheimer's and Dementia, 15(6), 817-827. Elsevier Alzheimers & Dementia r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Alzheimer's & dementia : the journal of the Alzheimer's Association Alzheimer's & dementia Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, D J, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, Ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, De Roeck, E, Sleegers, K, Bordet, R, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, G B, Molinuevo, J L, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, P J, Lovestone, S & Legido-Quigley, C 2019, ' Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort ', Alzheimer's & Dementia, vol. 15, no. 6, pp. 817-827 . https://doi.org/10.1016/j.jalz.2019.03.004 Alzheimer's & Dementia, Vol. 15, No 6 (2019) pp. 817-827 Alzheimer's & Dementia, 15(6), 817-827. Elsevier Science |
| ISSN: | 1552-5260 1552-5279 |
| DOI: | 10.1016/j.jalz.2019.03.004 |
| Popis: | Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers.Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis.Results: Eight metabolites were associated with amyloid b and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory.Discussion: PFAMs have been found increased and associated with amyloid b burden in CSF and clinical measures. Crown Copyright (C) 2019 Published by Elsevier Inc. on behalf of the Alzheimer's Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). |
| Databáze: | OpenAIRE |
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