The impact of the social construct of race on outcomes among bacille Calmette‐Guérin‐treated patients with high‐risk non‐muscle–invasive bladder cancer in an equal‐access setting
| Autor: | Meagan L. Foster, Emily Wiggins, Stephen J. Freedland, Amanda De Hoedt, Aditya Srinivasan, Lauren E. Howard, Zachary Klaassen, Stephen B. Williams, Dan Theodorescu, Corinne Lawler, Brandee Branche, Jeffrey R. Gingrich, Lin Gu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Urinary Bladder Bacille Calmette Guerin Race (biology) Adjuvants Immunologic Internal medicine medicine Humans Neoplasm Invasiveness Socioeconomic status Proportional Hazards Models Bladder cancer Proportional hazards model business.industry Hazard ratio medicine.disease Progression-Free Survival Confidence interval Administration Intravesical Urinary Bladder Neoplasms Oncology BCG Vaccine Neoplasm Recurrence Local Non muscle invasive business |
| Zdroj: | Cancer. 127:3998-4005 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.33792 |
| Popis: | BACKGROUND The objective of this study was to describe bladder cancer outcomes as a function of race among patients with high-risk non-muscle-invasive bladder cancer (NMIBC) in an equal-access setting. METHODS A total of 412 patients with high-risk NMIBC who received bacille Calmette-Guerin (BCG) from January 1, 2010, to December 31, 2015, were assessed. The authors used the Kaplan-Meier method to estimate event-free survival and Cox regression to determine the association between race and recurrence, progression, disease-specific, and overall survival outcomes. RESULTS A total of 372 patients who had complete data were included in the analysis; 48 (13%) and 324 (87%) were Black and White, respectively. There was no difference in age, sex, smoking status, or Charlson Comorbidity Index by race. White patients had a higher socioeconomic status with a greater percentage of patients living above the poverty level in comparison with Black patients (median, 85% vs 77%; P < .001). A total of 360 patients (97%) received adequate induction BCG, and 145 patients (39%) received adequate maintenance BCG therapy. There was no significant difference in rates of adequate induction or maintenance BCG therapy according to race. There was no significant difference in recurrence (hazard ratio [HR], 1.53; 95% confidence interval [CI], 0.64-3.63), progression (HR, 0.77; 95% CI, 0.33-1.82), bladder cancer-specific survival (HR, 1.01; 95% CI, 0.30-3.46), or overall survival (HR, 0.97; 95% CI, 0.56-1.66) according to Black race versus White race. CONCLUSIONS In this small study from an equal-access setting, there was no difference in the receipt of BCG or any differences in bladder cancer outcomes according to race. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text