The Association between the Triglyceride to High-density Lipoprotein Cholesterol Ratio and Low-density Lipoprotein Subclasses
| Autor: | Kengo Moriyama |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
small dense low-density lipoprotein cholesterol 030204 cardiovascular system & hematology chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Japan Medicine malondialdehyde-modified low-density lipoprotein atherosclerotic cardiovascular disease General Medicine Middle Aged triglyceride to high-density lipoprotein cholesterol ratio Cholesterol Editorial Cardiovascular Diseases LDL particle size Low-density lipoprotein Regression Analysis Female Original Article lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology Multiple linear regression analysis coronary artery disease Adult medicine.medical_specialty TG/HDL-C ratio Risk Assessment 03 medical and health sciences Insulin resistance Asian People Internal medicine Linear regression Internal Medicine Humans Triglycerides Aged Triglyceride business.industry Cholesterol HDL Cholesterol LDL Atherosclerosis medicine.disease Endocrinology ROC Curve chemistry Insulin Resistance business Lipoprotein |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Objective The triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio is related to insulin resistance (IR). However, information about whether or not the TG/HDL-C ratio is associated with low-density lipoprotein (LDL) subclasses in the Japanese population is limited. Methods In total, 1,068 Japanese subjects who underwent an annual health examination and who were not taking medications were recruited. The association between the TG/HDL-C ratio and LDL subclasses was investigated using correlation, multiple regression, and receiver operating characteristic analyses. Results A correlation analysis revealed that both malondialdehyde-modified low-density lipoprotein (MDA-LDL) and small dense low-density lipoprotein cholesterol (sdLDL-C) were positively associated with the TG/HDL-C ratio. Furthermore, a multiple linear regression analysis revealed that the TG/HDL-C ratio was positively associated with MDA-LDL and sdLDL-C in both men and women. The multiple logistic regression analysis also revealed that the TG/HDL-C ratio was positively associated with the upper tertile of MDA-LDL and sdLDL-C in men and women. The LDL-C levels increased with the increasing TG/HDL-C ratio. The MDA-LDL and sdLDL-C are known to be positively associated with LDL-C. However, within the same LDL-C range, both MDA-LDL and sdLDL-C levels increased with the TG/HDL-C ratio, except for MDA-LDL levels in the LDL-C |
| Databáze: | OpenAIRE |
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