Immunosurveillance and immunotherapy of tumors by innate immune cells

Autor: David H. Raulet, Assaf Marcus, Thornton W Thompson, Alexandre Iannello, Michele Ardolino
Rok vydání: 2016
Předmět:
Antigens
Differentiation
T-Lymphocyte
0301 basic medicine
Interleukin 21
Neoplasms
Receptors
Killer Cells
Innate
2.1 Biological and endogenous factors
Immunology and Allergy
Aetiology
Immunologic Surveillance
Cancer
Innate lymphoid cell
DNA
Neoplasm
Natural killer T cell
Acquired immune system
Neoplasm Proteins
Gene Expression Regulation
Neoplastic
Killer Cells
Natural
Differentiation
Natural
Interleukin 12
Receptors
Natural Killer Cell
Immunotherapy
Signal Transduction
Immunology
Biology
Article
Vaccine Related
03 medical and health sciences
Immune system
Animals
Humans
Antigens
Neoplastic
Lymphokine-activated killer cell
Innate immune system
Inflammatory and immune system
Macrophages
Immunity
DNA
Immunity
Innate
030104 developmental biology
T-Lymphocyte
Gene Expression Regulation
Cancer research
Neoplasm
Immunization
Natural Killer Cell
Zdroj: Current opinion in immunology, vol 38
Iannello, A; Thompson, TW; Ardolino, M; Marcus, A; & Raulet, DH. (2016). Immunosurveillance and immunotherapy of tumors by innate immune cells. Current Opinion in Immunology, 38, 52-58. doi: 10.1016/j.coi.2015.11.001. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/9t3505px
ISSN: 0952-7915
DOI: 10.1016/j.coi.2015.11.001
Popis: © 2015 Elsevier Ltd. Increasing evidence supports a role for innate immune effector cells in tumor surveillance. Natural killer (NK) cells and myeloid cells represent the two main subsets of innate immune cells possessing efficient but quite different tumor suppressive abilities. Here, we describe the germline-encoded NK cell receptors that play a role in suppressing tumor development and describe briefly the cellular pathways leading to the upregulation of their ligands in tumor cells. We also describe mechanisms underlying the elimination of tumor cells by macrophages and a recently characterized mechanism dedicated to sensing cytosolic DNA that is implicated in antitumor immune responses.
Databáze: OpenAIRE
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