Clinical, diagnostic and biochemical features of generalised glycogenosis type II in Brahman cattle
| Autor: | Reichmann Kg, E. J. Thistlethwaite, Twist Jo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Central Nervous System
Male Pathology medicine.medical_specialty Central nervous system Cattle Diseases Oligosaccharides Eye Purkinje Fibers chemistry.chemical_compound Glycogen storage disease type II medicine Animals Aspartate Aminotransferases Creatine Kinase Neurons General Veterinary Glycogen biology Glycogen Storage Disease Type II Muscles Myocardium Skeletal muscle alpha-Glucosidases General Medicine medicine.disease Spinal cord Staining medicine.anatomical_structure chemistry biology.protein Cattle Female Creatine kinase Cytoplasmic Vacuolation |
| Zdroj: | Australian Veterinary Journal. 70:405-408 |
| ISSN: | 1751-0813 0005-0423 |
| DOI: | 10.1111/j.1751-0813.1993.tb06073.x |
| Popis: | Clinical, diagnostic and biochemical features of generalised glycogenosis are described in 96 Brahman-type calves. Typically the calves were presented when about 6 months of age, with ill-thrift and muscular weakness as the most common signs. Acidic alpha-glucosidase activity was reduced in peripheral blood lymphocytes and skeletal muscle. Muscle glycogen concentration was consistently higher in affected animals than in clinically normal cattle. Other observations in affected calves included elevation of serum aspartate aminotransferase and creatine kinase activities and excessive amounts of high molecular weight oligosaccharides in urine. Fine cytoplasmic vacuolation of neurones in the brain and spinal cord, skeletal muscle, myocardium and of Purkinje fibres were consistent histological observations. Periodic acid-Schiff staining revealed the presence of glycogen-like material in peripheral blood lymphocytes of all affected calves, indicating that this is a useful aid for the diagnosis of glycogenosis. While 3 of the 96 calves showed somewhat different clinical signs, the similarity of pathology and the biochemical and clinical evidence in the remainder suggested that, in these animals, the disease was expressed as a single syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text