| Autor: |
Menglu Li, Hao-Xiang Liao, Kazuki Bando, Yasunori Nawa, Satoshi Fujita, Katsumasa Fujita |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Analytical chemistry. 94(28) |
| ISSN: |
1520-6882 |
| Popis: |
Simultaneous observation of drug distribution at the effector site and subsequent cell response are essential in the drug development process. However, few studies have visualized the drug itself and biomolecular interactions in living cells. Here, we used label-free Raman microscopy to investigate drug-induced cytotoxicity and visualize drug uptake and subcellular localization by its specific molecular fingerprint. A redox-sensitive Raman microscope detected the decrease of reduced cytochrome |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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