Hanshiyi Formula, a medicine for Sars-CoV2 infection in China, reduced the proportion of mild and moderate COVID-19 patients turning to severe status: A cohort study
Autor: | Zezheng Gao, Baoyan Liu, Xiaowen Gou, Haoran Wu, Liyun He, Xiuyang Li, Jiaxing Tian, Xiaolin Tong, Fengmei Lian, Yujiao Zheng, Han Wang, Yanke Ai, Shiyan Yan, Ying Zhang, Lei Zhang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Adolescent Moderate COVID-19 Traditional Chinese medicine Disease Article Cohort Studies Young Adult 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine medicine Humans Young adult Medical prescription Child ComputingMethodologies_COMPUTERGRAPHICS Aged Aged 80 and over Pharmacology business.industry Infant Newborn COVID-19 Infant Retrospective cohort study Odds ratio Middle Aged Mild COVID-19 COVID-19 Drug Treatment The proportion to severe status Treatment Outcome 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis Propensity score matching Disease Progression Hanshiyi Formula Female business Drugs Chinese Herbal Cohort study |
Zdroj: | Pharmacological Research |
ISSN: | 1043-6618 |
DOI: | 10.1016/j.phrs.2020.105127 |
Popis: | Graphical abstract We formulated a traditional Chinese medicine (TCM) prescription, Hanshiyi Formula (HSYF), which was approved and promoted by the Wuhan Municipal Health Commission for treating mild and moderate coronavirus disease 2019 (COVID-19). We aimed to evaluate the effect of HSYF on the progression to severe disease in mild and moderate COVID-19 patients. We conducted a retrospective cohort study of patients with mild and moderate COVID-19 in a quarantine station in Wuchang District, Wuhan. Using the real-time Internet information collection application and Centers for Disease Control for the Wuchang District, patient data were collected through patient self-reports and follow-ups. HSYF intervention was defined as the exposure. The primary outcome was the proportion of patients who progressed to a severe disease status, and a stratification analysis was performed. Univariate and multivariate regression analyses were performed to identify influencing factors that may affect the outcome. Further, we used propensity score matching (PSM) to assess the effect of HSYF intervention on the conversion of mild and moderate to a severe disease status. Totally, 721 mild and moderate COVID-19 patients were enrolled, including 430 HSYF users (exposed group) and 291 non-users (control group). No cases in the exposed group and 19 (6.5 %, P < 0.001) cases in the control group progressed to severe disease, and the difference between the two groups (exposed group-control group) was −6.5 % [95 % confidence interval (CI): (−8.87 %, −4.13 %)]. Univariate regression analysis revealed sex (male), age, fever, cough, and fatigue as risk factors for progression to severe disease. After PSM, none of the HSYF users and 7 (4.7 %, P = 0.022) non-users transitioned to severe disease, and the difference between the two groups (exposed group-control group) was −4.7 % [95 % CI: (−8.2 %, −1.2 %)]. Multivariate regression analysis revealed that sex (male) [OR: 3.145; 95 % CI: 1.036–9.545; P = 0.043] and age (> 48 years) [odds ratio (OR): 1.044; 95 % CI: 1.001–1.088; P = 0.044] were independent risk factors for conversion to severe disease. Therefore, HSYF can significantly reduce the progression to severe disease in patients with mild and moderate COVID-19, which may effectively prevent and treat the disease. However, further larger clinical studies are required to verify our results. |
Databáze: | OpenAIRE |
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