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Department of Medicinal Chemistry, Department of Microbiology, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, Uttar Pradesh, India E-mail : tryambak@yahoo.com Manuscript received online 07 July 2014, revised 07 August 2014, accepted 01 September 2014 The weak base and strong base fractions were separated from methanolic extract of roots of Anisodus luridus. Chromatographic resolution of both fractions yielded compounds 1-5 which were characterized as β-sitosterol (1), esculetin (2), β-sitosterol-β-D-glucoside (3), apohyoscyamine (4) and hyoscyamine (5) with the help of spectroscopic analysis. Four compounds, 1-4 were isolated from A. luridus for the first time. The weak base, strong base and isolated constituents were screened against six microbes viz. E. coli, S. aureus, E. faecalis, C. albicans, C. tropicalis and C. krusei. Weak base, strong base and isolated pure compounds exhibited their potential against these microbes. |
