Validation of coronary flow reserve measurements by thermodilution in clinical practice

Autor: Gerald S. Werner, Keith G. Oldroyd, Emanuele Barbato, Wilbert Aarnoudse, Waldemar Bojara, Wim R.M. Aengevaeren, Istvan Herzfeld, Nico H.J. Pijls, Bernard De Bruyne, Volker Klauss
Přispěvatelé: Barbato, Emanuele, Aarnoudse, W, Aengevaeren, Wr, Werner, G, Klauss, V, Bojara, W, Herzfeld, I, Oldroyd, Kg, Pijls, Nhj, De Bruyne, B., Biomedical Engineering, Cardiovascular Biomechanics
Jazyk: angličtina
Rok vydání: 2004
Předmět:
Coronary flow reserve
Thermodilution
Fractional flow reserve
Ischaemia
Coronary artery disease
coronary artery blood flow
validation process
Coronary Circulation
Medicine
Heart
lung and circulation [UMCN 2.1]
Ultrasonography
algorithm
article
calculation
clinical practice
clinical trial
correlation coefficient
Doppler flowmetry
feasibility study
guide wire
human
injection
major clinical study
multicenter study
priority journal
reliability
thermodilution
validation process
Coronary Circulation
Feasibility Studies
Humans
Doppler
Improved algorithm
Clinical Practice
medicine.anatomical_structure
Cardiology
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
Coronary circulation
Internal medicine
business.industry
Ultrasonography
Doppler
medicine.disease
Pressure wire
Surgery
Feasibility Studie
business
Zdroj: European Heart Journal, 25, 3, pp. 219-23
European Heart Journal, 25(3), 219-223. Oxford University Press
European Heart Journal, 25, 219-23
ISSN: 1522-9645
0195-668X
Popis: Background: Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFR thermo obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR Doppler). Methods and results: In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermo and CFRDoppler were measured. FFR could be obtained in all patients (100%). An optimal CFRDoppler could be obtained in 69% of the patients. CFRthermo could be obtained in 97% of the patients. A significant correlation was found between CFRDoppler and CFR thermo (r=0.79, Pthermo tended to be higher than CFRDoppler. Conclusions: In a setting close to 'real world' practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation.
Databáze: OpenAIRE
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