Validation of coronary flow reserve measurements by thermodilution in clinical practice
Autor: | Gerald S. Werner, Keith G. Oldroyd, Emanuele Barbato, Wilbert Aarnoudse, Waldemar Bojara, Wim R.M. Aengevaeren, Istvan Herzfeld, Nico H.J. Pijls, Bernard De Bruyne, Volker Klauss |
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Přispěvatelé: | Barbato, Emanuele, Aarnoudse, W, Aengevaeren, Wr, Werner, G, Klauss, V, Bojara, W, Herzfeld, I, Oldroyd, Kg, Pijls, Nhj, De Bruyne, B., Biomedical Engineering, Cardiovascular Biomechanics |
Jazyk: | angličtina |
Rok vydání: | 2004 |
Předmět: |
Coronary flow reserve
Thermodilution Fractional flow reserve Ischaemia Coronary artery disease coronary artery blood flow validation process Coronary Circulation Medicine Heart lung and circulation [UMCN 2.1] Ultrasonography algorithm article calculation clinical practice clinical trial correlation coefficient Doppler flowmetry feasibility study guide wire human injection major clinical study multicenter study priority journal reliability thermodilution validation process Coronary Circulation Feasibility Studies Humans Doppler Improved algorithm Clinical Practice medicine.anatomical_structure Cardiology Cardiology and Cardiovascular Medicine medicine.medical_specialty Coronary circulation Internal medicine business.industry Ultrasonography Doppler medicine.disease Pressure wire Surgery Feasibility Studie business |
Zdroj: | European Heart Journal, 25, 3, pp. 219-23 European Heart Journal, 25(3), 219-223. Oxford University Press European Heart Journal, 25, 219-23 |
ISSN: | 1522-9645 0195-668X |
Popis: | Background: Coronary flow reserve (CFR) and fractional flow reserve (FFR) provide complementary information on the coronary circulation. Using a pressure wire, it is possible to calculate CFR by thermodilution (CFRthermo), so that FFR and CFR can be measured with a single guide wire. The present multicentric study was performed to compare the feasibility of CFR thermo obtained with an improved algorithm and a standardized injection technique and its agreement with Doppler-derived CFR (CFR Doppler). Methods and results: In 86 patients with coronary artery disease recruited during 1 week in eight centres FFR, CFRthermo and CFRDoppler were measured. FFR could be obtained in all patients (100%). An optimal CFRDoppler could be obtained in 69% of the patients. CFRthermo could be obtained in 97% of the patients. A significant correlation was found between CFRDoppler and CFR thermo (r=0.79, Pthermo tended to be higher than CFRDoppler. Conclusions: In a setting close to 'real world' practice, this multicentric study confirms the feasibility and reliability of thermodilution-derived CFR. In addition, the safety and the swiftness of assessing FFR and CFR with one single guide wire makes the latter a unique clinical tool for the evaluation of the coronary circulation. |
Databáze: | OpenAIRE |
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