Occupational risk assessment of exposure to metals in chrome plating workers
| Autor: | Cristina Deuner Muller, Evandro Oliveira, Thereza Luciano Trombini, Natália Brucker, Aline Belem Machado, Larissa Machado Lacerda, Gabriela Göethel, Elisa Sauer, Anelise Pressotto, Luciane Rosa Feksa, Solange Cristina Garcia, Virginia Cielo Rech, Cláudia Regina Klauck, Adriana Gioda, Luciano Basso da Silva |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chromium
Male Chrome plating DNA damage Health Toxicology and Mutagenesis chemistry.chemical_element 010501 environmental sciences Toxicology medicine.disease_cause Risk Assessment 01 natural sciences Andrology Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Occupational Exposure medicine Humans Carcinogen 0105 earth and related environmental sciences Pharmacology Chemical Health and Safety Public Health Environmental and Occupational Health General Medicine Comet assay chemistry Metals visual_art visual_art.visual_art_medium Comet Assay Micronucleus 030217 neurology & neurosurgery Genotoxicity |
| Zdroj: | Drug and Chemical Toxicology. 45:560-567 |
| ISSN: | 1525-6014 0148-0545 |
| DOI: | 10.1080/01480545.2020.1731527 |
| Popis: | Inhalation of xenobiotics during manufacture process in chrome plating bath produce hazards to workers' health. Chromium (Cr) is a metal widely used by industry, and its hexavalent (VI) form has been classified as mutagenic and carcinogenic. This study aimed to evaluate the occupational risk of exposure to metals in chrome plating workers. Biological monitoring was performed through quantification of Cr, Pb, As, Ni, and V in blood by ICP-MS in 50 male chrome-plating workers from the exposed group and 50 male non-exposed workers. The inflammatory parameters assessed were β-2 integrin, intercellular adhesion molecule-1 (ICAM-1), and L-selectin expression in lymphocytes. The genotoxicity was evaluated with comet and micronucleus (MN) assays and as a biomarker of oxidative damage the lipid peroxidation (MDA) and protein carbonyl (PCO). The results demonstrated that Cr levels in blood and urine were increased in the exposed group compared to the non-exposed group. Although the biomarkers of exposure proved to be within the levels considered safe in exposed individuals, chrome plating workers presented significantly increase in the percentage of lymphocytes expressing β-2 integrin, ICAM-1, and L-selectin as well as DNA damage (comet assay) and plasmatic MDA and PCO levels. Therefore, it is possible also assign the injuries caused to lipids, proteins, and DNA assessed due to the increased presence of other metals such as Pb, As, Ni, and V in exposed subjects. These results suggest that exposure to xenobiotics present in the occupational environment in chrome plating industry could play a crucial role toward the inflammation, genetic, and oxidative damage. |
| Databáze: | OpenAIRE |
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