Thrombosis in Behcet's disease: a retrospective survey from a single UK centre
| Autor: | P. R. J. Ames, A. M. Denman, A. Pap, A. Steuer |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Population Behcet's disease Vascular occlusion Thrombophlebitis Cohort Studies Rheumatology Internal medicine Prevalence Humans Medicine Pharmacology (medical) Risk factor education Retrospective Studies Sex Characteristics education.field_of_study business.industry Behcet Syndrome Data Collection Thrombosis Middle Aged medicine.disease United Kingdom Surgery Venous thrombosis Relative risk Female medicine.symptom business |
| Zdroj: | Rheumatology. 40:652-655 |
| ISSN: | 1460-2172 |
| Popis: | Objective. To contribute to knowledge of vascular occlusion in Behcet's disease (BD), prevalence and relative risk for thrombosis were ascertained retrospectively in a cohort of Caucasian patients with the disease. Patients. The study included 73 BD patients (36 males, 37 females, mean age 45 ± 11 yr) attending the Immunology/Rheumatology Department of Northwick Park Hospital. A group of 146 patients without BD, attending the same department, served as a control group. Results. Thrombosis was more frequent in BD patients than in controls (23/73, 32% vs 7/146, 5%, P < 0.001). This was accounted for by a higher prevalence of venous thrombosis in BD patients (18 73, 25% vs 4/146, 3%, P < 0.001). Gender-adjusted data revealed an 11-fold risk of developing any thrombosis and a 14-fold risk of developing venous thrombosis in BD. After adjusting for differences in age at first symptoms, male BD patients showed a 6-fold higher risk of vein thrombosis. Males reported more often thrombophlebitis (13/36, 36% vs 0/0, P < 0.001). folliculitis (8/36, 22% vs 1/37, 3%, P < 0.01) and retinal vasculitis (13/36, 36%, vs 4/37, 11%, P = 0.01) than females, in whom arthralgia prevailed (23/37, 62%, vs 12/36, 33%, P = 0.01). Conclusion. In our population, BD confers a 14-fold risk of developing venous thrombosis. The risk is sixfold higher in male BD patients, who fare worse than females with regard to thrombophlebitis, folliculitis and retinal vasculitis. |
| Databáze: | OpenAIRE |
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