Cyclonellin, a New Cyclic Octapeptide from the Marine Sponge Axinella carteri
| Autor: | Barry R. O'keefe, Mohammad A. Rashid, Michael R. Boyd, Lewis K. Pannell, Dennis J. Milanowski, Joseph P. Nawrocki, Kirk R. Gustafson |
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| Rok vydání: | 2004 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Peptide Peptides Cyclic Analytical Chemistry Drug Discovery Tumor Cells Cultured Animals Humans Nuclear Magnetic Resonance Biomolecular Pharmacology chemistry.chemical_classification Pacific Ocean Molecular Structure biology Edman degradation Organic Chemistry Absolute configuration Protein primary structure biology.organism_classification Cyclic peptide Porifera Amino acid Sponge Complementary and alternative medicine chemistry Molecular Medicine Acid hydrolysis Drug Screening Assays Antitumor Micronesia |
| Zdroj: | Journal of Natural Products. 67:441-444 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np030336x |
| Popis: | Cyclonellin (1), a new cyclic octapeptide, was isolated from an aqueous extract of the marine sponge Axinella carteri. Its structure was elucidated by interpretation of NMR spectral data of the intact compound and N-terminal Edman sequencing of linear peptide fragments obtained by partial hydrolysis of 1. The absolute configurations of the constituent amino acids were determined by acid hydrolysis, derivitization with FDAA, and LC-MS analyses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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