Glutamate-mediated neuroplasticity in a limbic input to the hypothalamus

Autor:	J. L. Tartar, M. A. King, D. P. Devine
Rok vydání:	2006
Předmět:	Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Physiology Glutamic Acid Pituitary-Adrenal System Stimulation Evoked field Biology Receptors N-Methyl-D-Aspartate Behavioral Neuroscience Stress Physiological Internal medicine Neuroplasticity medicine Animals Rats Long-Evans Evoked Potentials Neuronal Plasticity Endocrine and Autonomic Systems Glutamate receptor Electric Stimulation Rats Psychiatry and Mental health Stria terminalis Neuropsychology and Physiological Psychology Endocrinology medicine.anatomical_structure nervous system Hypothalamus NMDA receptor Septal Nuclei Dizocilpine Maleate Neuroscience Nucleus hormones hormone substitutes and hormone antagonists Paraventricular Hypothalamic Nucleus
Zdroj:	Stress. 9:13-19
ISSN:	1607-8888 1025-3890
DOI:	10.1080/10253890600556481
Popis:	Emotionally-salient stressors are processed by cortical and limbic circuits that provide important regulatory input to the hypothalamic-pituitary-adrenal (HPA) axis. However, exposure to chronic or severe stress may cause disregulation of the axis and a variety of physiological and psychological symptoms. The mechanisms that underlie stress-induced alterations in HPA axis function are not well characterized, but one possibility is that severe stress causes plastic changes in limbic inputs to the hypothalamus. We examined plasticity within the bed nucleus of stria terminalis (BNST) and the hypothalamic paraventricular nucleus (PVN) with a stimulating electrode in the BNST and a recording electrode in the PVN. High-frequency BNST stimulation produced long-lasting suppression of evoked field potentials recorded from the PVN, and this effect was blocked by administration of MK-801. Accordingly, rapid glutamate-mediated neuroplasticity in the BNST to PVN neurocircuitry may contribute to plasticity in limbic regulation of the HPA axis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7554b5717a753a8424c4ee9ae9ecc350 https://doi.org/10.1080/10253890600556481 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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