Bisphenol A (BPA) induces progesterone receptor expression in an estrogen receptor α-dependent manner in perinatal brain
| Autor: | Allyssa Fahrenkopf, Christine K. Wagner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
endocrine system Offspring Estrogen receptor 010501 environmental sciences Biology Toxicology 01 natural sciences Article Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Developmental Neuroscience Phenols Pregnancy Internal medicine Progesterone receptor medicine Ingestion Animals Estrogens Non-Steroidal Benzhydryl Compounds 0105 earth and related environmental sciences Fetus Antagonist Estrogen Receptor alpha Preoptic Area Xenoestrogen Endocrinology chemistry Prenatal Exposure Delayed Effects Gestation Female Receptors Progesterone 030217 neurology & neurosurgery hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neurotoxicol Teratol |
| Popis: | Bisphenol A (BPA) is a xenoestrogen that is prevalent in the environment of industrialized nations due its use in the production of many plastic household items. Virtually all adults in the U.S. have detectable levels of BPA in urine and it can be measured in fetal serum and in breastmilk, making developmental exposure a particular concern. The present study utilizes a progesterone receptor (PR) expression bioassay to assess the estrogen receptor α (ERα)-dependent effects of BPA in fetal rodent brain following maternal exposure. Maternal ingestion of 10 μg/kg/day, but not 50 μg/kg/day, BPA from gestational day 14–22 significantly increased levels of PR immunoreactivity (PRir) in the medial preoptic nucleus (MPN) of female offspring. PR expression in the perinatal MPN is highly dependent on the activation of ERα, but not ERβ, by estrogens. Indeed, injections of BPA (5 μg/kg) to neonates from postnatal day 2–4 (P2–4) significantly increased PR expression in the MPN of postnatal day 5 females compared to the MPN of females administered the oil vehicle. However, pretreatment with the ER antagonist, ICI 182,780 from P1–4 significantly attenuated the effects of BPA on PR expression, indicating an ERα-dependent mechanism. The present results also demonstrate a non-monotonic effect of BPA on the direct expression of a transcription factor in developing brain. |
| Databáze: | OpenAIRE |
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