Analysis of association between common variants in theSLCO6A1gene with schizophrenia, bipolar disorder and major depressive disorder in the Han Chinese population
| Autor: | Yongyong Shi, Weidong Ji, Wenjin Li, Jiawei Shen, Zhijian Song, Jianhua Chen, Qingzhong Wang, Yifeng Xu, Meng Wang, Zujia Wen, Zhiqiang Li, Raja Amjad Waheed Khan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male China Bipolar Disorder Organic Anion Transporters Genome-wide association study Polymorphism Single Nucleotide Young Adult 03 medical and health sciences 0302 clinical medicine Asian People medicine Humans Genetic Predisposition to Disease Bipolar disorder Gene Biological Psychiatry Genetic association Genetics Depressive Disorder Major Haplotype Case-control study Middle Aged medicine.disease 030227 psychiatry Solute carrier family Psychiatry and Mental health Haplotypes Case-Control Studies Schizophrenia Major depressive disorder Female Psychology 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | The World Journal of Biological Psychiatry. 17:140-146 |
| ISSN: | 1814-1412 1562-2975 |
| DOI: | 10.3109/15622975.2015.1126676 |
| Popis: | The SLCO6A1 gene belongs to a superfamily of genes which is known to be a solute carrier family of OATPs (SLCO). The SLCO6A1 gene encodes OATP6A1 protein in humans. A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia. To further investigate whether this gene is also a risk locus for schizophrenia (SCZ), bipolar disorder (BPD) and major depressive disorder (MDD) in the Han Chinese population, a case-control study was designed.In total 1,248 unrelated SCZ cases, 1,344 BPD cases, 1,056 unrelated MDD cases and 1,248 normal controls were analysed in this study. We genotyped five SNPs using the Sequenom MassARRAY platform.We found no association of rs6878284 with SCZ [Corrected Pallele = 0.969, Corrected Pgenotype = 0.997]. Furthermore, we found a statistically significant association of the rs7734060 genotype with MDD after correction [rs7734060: Corrected Pallele = 0.114, Corrected Pgenotype = 0.036] in the Han Chinese population.This is the first study which reveals no association of rs6878284 with SCZ and also predicts that rs7734060 could be a risk locus for MDD in the Han Chinese population. |
| Databáze: | OpenAIRE |
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