Is Bdnf-Val66Met Polymorphism Associated With Psychotic Experiences And Psychotic Disorder Outcome? Evidence From A 6 Years Prospective Population-Based Cohort Study

Autor: Hayriye Elbi, Jim van Os, Umut Kirli, Köksal Alptekin, Tolga Binbay, Duygu Keskin Gokcelli, Bülent Kayahan, Ferda Ozkinay, Hüseyin Onay, Marjan Drukker
Přispěvatelé: Ege Üniversitesi, Promovendi MHN, Psychiatrie & Neuropsychologie, RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3)
Rok vydání: 2019
Předmět:
Male
SYMPTOMS
CANDIDATE GENES
Cohort Studies
0302 clinical medicine
FACTOR GENE
Polymorphism (computer science)
Risk Factors
Epidemiology
SCHIZOPHRENIA
Longitudinal Studies
Prospective Studies
Prospective cohort study
Genetics (clinical)
RISK
education.field_of_study
Mental Disorders
NEUROTROPHIC FACTOR VAL66MET
BIPOLAR DISORDER
Middle Aged
Psychiatry and Mental health
Phenotype
Schizophrenia
transdiagnostic psychosis phenotype
Female
epidemiology
Adult
medicine.medical_specialty
Psychosis
Genotype
Population
extended psychosis phenotype
Polymorphism
Single Nucleotide
03 medical and health sciences
Cellular and Molecular Neuroscience
AGE
environmental factors
medicine
Humans
Genetic Predisposition to Disease
Bipolar disorder
Psychiatry
education
Aged
RECEPTOR
business.industry
Brain-Derived Neurotrophic Factor
medicine.disease
030227 psychiatry
BDNF
Psychotic Disorders
Case-Control Studies
ONSET
BDNF GENE
business
030217 neurology & neurosurgery
Blood sampling
Zdroj: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics, 180(2), 113. Wiley-Liss Inc.
American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 180(2), 113-121. Wiley
ISSN: 1552-4841
Popis: WOS: 000459452000003
PubMed ID: 29785763
There is little research on genetic risk for the extended psychosis phenotype ranging from psychotic experiences (PEs) to psychotic disorders (PDs). In this general population-based prospective cohort study, the longitudinal associations between BDNF-Val66Met polymorphism and the different levels of the extended psychosis phenotype were investigated. Addresses were contacted in a multistage clustered probability sampling frame covering 11 districts and 302 neighborhoods at baseline (n = 4011). A nested case-control study (n = 366) recruited individuals with PEs and PDs as well as individuals with no psychotic symptoms. In this subgroup, blood sampling for genetic analysis and assessment of environmental exposures were carried out, followed by clinical re-appraisal at follow-up 6 years later (n = 254). The BDNF-Val66Met polymorphism was significantly associated with the extended psychosis phenotype. The pattern of the association was that the BDNF-Val66Met polymorphism impacted in a dose-response but extra-linear fashion, with stronger impact at the PD end of the extended psychosis phenotype. Associations were still significant after adjusting for sociodemographic factors and environmental exposures including life events, childhood adversity, socioeconomic status, urbanicity, and cannabis use. The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum.
Turkiye Bilimsel ve Teknolojik Arastirma KurumuTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [107S053, 112S476]
Turkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Numbers: 107S053 and 112S476
Databáze: OpenAIRE
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