Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
| Autor: | Ning Liu, Libo Man, Jianpo Zhai, Guang-lin Huang, Hai Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
renal cell carcinoma Cancer Research medicine.medical_specialty characteristic Gastroenterology Resection 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma Internal medicine Medicine en bloc resection Pathological RC254-282 Original Research Visceral metastasis business.industry Proportional hazards model spinal bone metastasis Medical record Neoplasms. Tumors. Oncology. Including cancer and carcinogens Bone metastasis medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis prognosis business Median survival |
| Zdroj: | Frontiers in Oncology Frontiers in Oncology, Vol 11 (2021) |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2021.659779 |
| Popis: | BackgroundThe prognosis of renal cell carcinoma (RCC) with spinal bone metastasis (sBM) varies greatly. In this study, we aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM) in our center.MethodsThe clinical and medical records of RCC patients with sBMs were collected. The gender, age, time of BM, the extent of BM, the number of BMs, the presence or absence of visceral metastasis, and the pathological type of BM were investigated. All patients were followed up regularly. Overall survival (OS) was calculated from the date of BMs diagnosis to death or last follow-up using Kaplan-Meier method and modelled with Cox regression analysis.ResultsForty-three RCC patients with sBM were collected. sBM was found synchronously in 30 patients (70%) and metachronously in 13 patients (30%). The median survival time was 30 months in 13 patients (30%) with solitary sBM and 19 months in 30 patients (70%) with multiple sBMs (P = 0.002). Visceral metastasis occurred in 12 patients (28%) with the median survival time of 17 months, while the other 31 patients (72%) had no visceral metastasis with the median survival time of 29 months (PPConclusionsMSKCC risk stratification, number of sBM, visceral metastasis and en-block resection are significant prognostic factors for OS in RCC patients with spinal BM. Therefore, for selected patients who has solitary spinal BM with no visceral metastasis, en-block resection of spinal BM can potentially prolong survival and is the treatment of choice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|