The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall

Autor: Daniel F. J. Ketelhuth
Rok vydání: 2019
Předmět:
Kynurenine pathway
Physiology
Anti-Inflammatory Agents
Inflammation
Disease
Anti-Inflammatory Agents/therapeutic use
IDO
Immunomodulation
Energy Metabolism/drug effects
chemistry.chemical_compound
Immune system
Inflammation/drug therapy
Physiology (medical)
Diabetes mellitus
medicine
Indoleamine-Pyrrole 2
3
-Dioxygenase
Humans
Animals
Indoleamine 2
3-dioxygenase
Kynurenine
Immunomodulation/drug effects
Immunometabolism
business.industry
Tryptophan
Atherosclerosis/drug therapy
Arteries
Atherosclerosis
medicine.disease
Plaque
Atherosclerotic
Up-Regulation
Immune System/drug effects
chemistry
Arteries/drug effects
Immune System
Immunology
Tryptophan/immunology
Indoleamine-Pyrrole 2
3
-Dioxygenase/immunology
medicine.symptom
Energy Metabolism
Cardiology and Cardiovascular Medicine
business
Homeostasis
Signal Transduction
Zdroj: Ketelhuth, D F J 2019, ' The immunometabolic role of indoleamine 2 3-dioxygenase in atherosclerotic cardiovascular disease : immune homeostatic mechanisms in the artery wall ', Cardiovascular Research, vol. 115, no. 9, pp. 1408-1415 . https://doi.org/10.1093/cvr/cvz067
ISSN: 1755-3245
0008-6363
DOI: 10.1093/cvr/cvz067
Popis: Coronary heart disease and stroke, the two most common cardiovascular diseases worldwide, are triggered by complications of atherosclerosis. Atherosclerotic plaques are initiated by a maladaptive immune response triggered by accumulation of lipids in the artery wall. Hence, disease is influenced by several non-modifiable and modifiable risk factors, including dyslipidaemia, hypertension, smoking, and diabetes. Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in the kynurenine pathway of tryptophan (Trp) degradation, is modulated by inflammation and regarded as a key molecule driving immunotolerance and immunosuppressive mechanisms. A large body of evidence indicates that IDO-mediated Trp metabolism is involved directly or indirectly in atherogenesis. This review summarizes evidence from basic and clinical research showing that IDO is a major regulatory enzyme involved in the maintenance of immunohomeostasis in the vascular wall, as well as current knowledge about promising targets for the development of new anti-atherosclerotic drugs.
Databáze: OpenAIRE
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