Unsuccessful rechallenge with pemetrexed after a previous radiation recall dermatitis
| Autor: | Fabrice Barlesi, Celine Tummino, Anne-Marie Tasei, Philippe Astoul |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Oncology Cancer Research medicine.medical_specialty Guanine Lung Neoplasms medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Pemetrexed chemistry.chemical_compound Glutamates Carcinoma Non-Small-Cell Lung Internal medicine Humans Medicine Lung cancer Aged Chemotherapy business.industry Combination chemotherapy medicine.disease Carboplatin Gemcitabine Surgery Radiation therapy Radiation Recall Dermatitis chemistry Female Radiodermatitis business medicine.drug |
| Zdroj: | Lung Cancer. 54:423-425 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/j.lungcan.2006.06.021 |
| Popis: | Radiation recall dermatitis is characterized by an inflammatory reaction within a previously irradiated volume after administration of a drug. Antineoplastic drugs have mainly been involved in radiation recall reactions. This phenomenon is well known but poorly understood. Many hypotheses as stem-cell depletion in the radiotherapy field, heritable mutations within surviving stem cells, local vascular changes as well as a drug hypersensitivity reaction have been proposed to explain these reactions. In this report, we describe a non-small cell lung cancer patient treated with a carboplatin plus gemcitabine combination chemotherapy as first line followed by pemetrexed as second line therapy. Twenty-five years ago, she completed radiation therapy for breast cancer. Three days after the first cycle of pemetrexed, she presented with a radiation recall dermatitis. As EGFR-staining was negative, we rechallenged the patient with pemetrexed. Unfortunately, although less intense, we faced a recurrence of the skin reaction and pemetrexed was no longer continued. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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