α-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies—Part 1

Autor:	Sophie Poty, Lynn C. Francesconi, Jason S. Lewis, Michael J. Morris, Michael R. McDevitt
Rok vydání:	2018
Předmět:	03 medical and health sciences Radiochemistry 0302 clinical medicine Isotope Labeling 030220 oncology & carcinogenesis Humans Environmental science Radiology Nuclear Medicine and imaging Alpha Particles Continuing Education 030218 nuclear medicine & medical imaging
Zdroj:	Journal of Nuclear Medicine. 59:878-884
ISSN:	2159-662X 0161-5505
Popis:	With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754bdf66fdfd12ae53cffe4ee7235402 https://doi.org/10.2967/jnumed.116.186338 Zobrazit plný text záznamu