Association between hypertensive pregnancy disorders and future risk of stroke in Taiwan: a Nationwide population-based retrospective case-control study

Autor:	Shao Yi Lin, Chun Min Lo, Chien Chu Huang, Chang Huei Tsao, Wu Chou Lin, Chun Chung Huang, Chi-Hsiang Chung, Wu-Chien Chien, Fu Huang Lin, Cherry Yin-Yi Chang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Gestational hypertension medicine.medical_specialty Adolescent Taiwan Kaplan-Meier Estimate 030204 cardiovascular system & hematology lcsh:Gynecology and obstetrics Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Internal medicine medicine Humans Eclampsia Child Cerebrovascular disease Stroke lcsh:RG1-991 Proportional Hazards Models Retrospective Studies CVA Proportional hazards model business.industry Incidence Incidence (epidemiology) Hazard ratio Case-control study Obstetrics and Gynecology Retrospective cohort study Hypertension Pregnancy-Induced medicine.disease Case-Control Studies Female business Pre-eclampsia 030217 neurology & neurosurgery Research Article Forecasting
Zdroj:	BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-10 (2020) BMC Pregnancy and Childbirth
ISSN:	1471-2393
Popis:	Background The incidence of female stroke has increased gradually and has begun occurring at a younger age in recent years. Given that women live longer than men, stroke would cause more negative and longer-term impacts on the rest of the lives of women. There are few related studies on Asian women. We aimed to evaluate stroke risk in Asian women following hypertensive pregnancy disorders. Methods Using the Taiwan National Health Insurance database, we designed a retrospective study that included pregnant women between 2000 and 2013. We selected an age-matched control group of women without hypertensive pregnancy disorders at a 1:3 ratio. The endpoint was any episode of stroke; otherwise, the patients were tracked until December 31, 2013. After the index date until the end of 2013, Cox proportional hazards analysis was used to compare the risk of incident stroke. The risk factors for stroke were determined using Cox proportional regression to calculate the hazard ratio (HR) compared with the control group. Results During the follow-up period, the Kaplan-Meier analysis indicated that patients with hypertensive pregnancy disorders had a significantly higher risk of developing stroke than did patients without hypertensive pregnancy disorders (log-rank test P < 0.001). Multivariate Cox regression analysis demonstrated that the case group had a 2.134-fold increased risk of stroke (HR = 2.134; 95% CI = 1.817–2.505; P < 0.001). Conclusion Our study provided evidence of an increased risk of stroke in patients with hypertensive pregnancy disorders. Compared with those without such disorders, the patients who had experienced the disorders had a 2.134-fold (P
Databáze:	OpenAIRE
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