A comparative study of complete blood count inflammatory markers in substance-free acute psychotic disorder and substance-induced psychosis
| Autor: | Kurnaz Samet, Durmaz Onur, Akkişi Kumsar Neslihan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Psychosis
medicine.medical_specialty Neutrophils Lymphocyte Gastroenterology 03 medical and health sciences Leukocyte Count 0302 clinical medicine White blood cell Internal medicine medicine Humans Lymphocytes Neutrophil to lymphocyte ratio Biological Psychiatry Retrospective Studies medicine.diagnostic_test business.industry Monocyte fungi Complete blood count Retrospective cohort study medicine.disease Prognosis Substance-induced psychosis 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Pshychiatric Mental Health business 030217 neurology & neurosurgery |
| Zdroj: | Early intervention in psychiatryREFERENCES. 15(6) |
| ISSN: | 1751-7893 |
| Popis: | Aim Recent studies showed a compare complete blood count (CBC) with its related measurements, including neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), and platelet to lymphocyte ratio, are a simple and affordable test for inflammatory markers. The aim of this controlled study is to compare CBC inflammatory markers in substance-induced psychosis (SIP) and substance-free acute psychotic disorder (SF-APD) and to evaluate whether these CBC inflammation values can be used in diagnosis. Methods This retrospective study was conducted with the data of 76 SF-APD patients (including 60 cases of first-episode psychosis [FEP]), 98 SIP patients (including 48 cases of FEP), and 32 controls. Results Patients with SF-APD and SIP had higher white blood cell counts, neutrophil and monocyte counts, and MLR than controls. An increased NLR was more distinct in SF-APD, while an increased MLR was observed in APD (both SF and SI) and FEP groups more than in the controls. A receiver operating characteristic analysis showed that the NLR could contribute to the identification of SF-APD (52.6% sensitivity and 12.5% specificity, area under curve [AUC] = 0.704, 2.47 cutoff value) while an MLR could contribute to the identification of APD (70.1% sensitivity and 12.5% specificity, AUC = 0.842) as well as FEP (71.3% sensitivity and 12.5% specificity AUC = 0.831) with 0.26 cutoff value. Conclusions An NLR and MLR might be of interest for inflammatory processes involved in acute and first-episode psychotic events, regardless of substance involvement. |
| Databáze: | OpenAIRE |
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