The effects of negative periocular pressure on intraocular pressure
| Autor: | Paul Yoo, John P. Berdahl, C. Ross Ethier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Decompression
0301 basic medicine medicine.medical_specialty Intraocular pressure genetic structures Glaucoma Blood volume Aqueous humor Aqueous Humor Clinical study 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Ophthalmology Humans Medicine Intraocular Pressure Blood Volume Blindness business.industry Models Theoretical medicine.disease eye diseases Sensory Systems Episcleral venous pressure 030104 developmental biology 030221 ophthalmology & optometry sense organs business Venous Pressure Sclera Increased blood volume |
| Zdroj: | Experimental Eye Research. 191:107928 |
| ISSN: | 0014-4835 |
| DOI: | 10.1016/j.exer.2020.107928 |
| Popis: | Glaucoma is a major cause of blindness, and IOP reduction remains the only clinically-validated therapy. In this study, we analyze a novel IOP-lowering strategy that uses a modest negative pressure (vacuum) applied locally to the periorbital region by a pair of goggles with each lens individually connected to a programmable pump. Motivated by clinical data showing an IOP reduction, we used an existing validated lumped-parameter model of the eye to understand the putative mechanism of this treatment. The model considers aqueous humor dynamics, episcleral venous pressure, and changes in ocular blood volume to describe how IOP changes with time in response to an external perturbation. We find that clinical data are qualitatively and quantitatively consistent with model predictions if we include two primary mechanisms in the model: first, negative pressure application causes a relatively rapid increase in globe volume accompanied by increased blood volume in the eye. Second, negative pressure application reduces episcleral venous pressure, causing a slower adjustment of IOP due to altered aqueous humor dynamics. These results provide testable hypotheses that hopefully will lead to a fuller experimentally-driven understanding of how negative periocular pressure influences IOP. Evaluating the long-term effects of such treatments on glaucoma patients requires further clinical study. |
| Databáze: | OpenAIRE |
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