Preparation of glibenclamide nanocrystals by a simple laboratory scale ultra cryo-milling
| Autor: | Ledjan Malaj, Ela Hoti, Roberta Censi, Valentina Martena, Piera Di Martino |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Scanning electron microscope digestive oral and skin physiology technology industry and agriculture Analytical chemistry Bioengineering General Chemistry Liquid nitrogen Condensed Matter Physics Atomic and Molecular Physics and Optics Crystallinity Crystallography Differential scanning calorimetry Dynamic light scattering Modeling and Simulation Particle General Materials Science Particle size Dissolution |
| Zdroj: | Journal of Nanoparticle Research. 15 |
| ISSN: | 1572-896X 1388-0764 |
| Popis: | The objective of this study is to evaluate the ability to reduce the particle size of glibenclamide (GBC) to the nanometric scale through a very simple and well-known laboratory scale method, the laboratory scale ultra cryo-milling. The effect of milling on GBC crystalline properties and dissolution behaviour was deliberately evaluated in the absence of any surfactants as stabilizers. The milling procedure consisted in adding particles to liquid nitrogen and milling them by hand in a mortar with a pestle for different time intervals (15, 30, 40 min). For comparison, the same milling procedure was also applied without liquid nitrogen. The particle size reduction was evaluated for the coarsest samples (>3 μm) by measuring the particle Ferret’s diameter through scanning electron microscopy, while for the smallest one ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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