Effect of Marihuana on Intraocular and Blood Pressure in Glaucoma
| Autor: | William J. Crawford, Solomon S. Gelbart, John C. Merritt, Alfred L. Anduze, Paul C. Alexander |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male Tachycardia Intraocular pressure genetic structures Population Glaucoma Blood Pressure Vasodilation Hypotension Orthostatic Ciliary body Heart Rate Heart rate medicine Humans education Intraocular Pressure Aged Cannabis education.field_of_study Cannabinoids business.industry Arrhythmias Cardiac Middle Aged medicine.disease eye diseases Ophthalmology Blood pressure medicine.anatomical_structure Depression Chemical Anesthesia Female sense organs medicine.symptom business |
| Zdroj: | Ophthalmology. 87:222-228 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/s0161-6420(80)35258-5 |
| Popis: | Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|