Effect of a Chinese herbal formula, Shi-Bi-Lin, on an experimental model of allergic rhinitis
| Autor: | Charlie A. van Hasselt, Y.O. Wong, John K. S. Woo, Li H. Wang, Ping C. Leung, George G. Chen, Yu Zhao |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Pulmonary and Respiratory Medicine
Histamine H1 Antagonists Non-Sedating Leukotrienes Allergy Nitric Oxide Synthase Type III Ovalbumin Thromboxane Guinea Pigs Immunology Nitric Oxide Synthase Type II Sneezing chemistry.chemical_compound Anti-Allergic Agents medicine Animals Immunology and Allergy Rhinitis Leukotriene rhinorrhea business.industry Immunoglobulin E Loratadine Eosinophil Nasal Lavage Fluid medicine.disease Eosinophils Thromboxane B2 Disease Models Animal Nasal Mucosa medicine.anatomical_structure chemistry Immunoglobulin G medicine.symptom business Anaphylaxis Histamine Drugs Chinese Herbal |
| Zdroj: | Annals of Allergy, Asthma & Immunology. 96:844-850 |
| ISSN: | 1081-1206 |
| DOI: | 10.1016/s1081-1206(10)61348-8 |
| Popis: | Background Jia Wei Cang Er Zi San , a traditional Chinese herbal formula, has been used to treat allergic rhinitis (AR) for several centuries. However, its effect on experimental animal models and its therapeutic mechanism remain unclear. Objective To study the effect of Shu-Bi-Lin, a modified Jia Wei Cang Er Zi San , on an animal model of AR. Methods Shu-Bi-Lin was administered to the guinea pig model of AR. Meanwhile, an antihistamine-treated group for the treatment control, an ovalbumin-sensitized and untreated group for the positive control, and a sham-sensitized, sham-challenged group for the sham control were studied in parallel. Symptomatic and some pathophysiologic variables were evaluated. Results Sneezing and nasal scratching after challenges were significantly ameliorated in the Shu-Bi-Lin-treated group compared with the ovalbumin-sensitized and untreated group, but rhinorrhea volume was not reduced. Shu-Bi-Lin significantly suppressed the production of IgG1 in the passive cutaneous anaphylaxis test. The thromboxane B 2 level in nasal lavage fluid was significantly deceased in the Shu-Bi-Lin-treated group; however, the reduction in histamine and peptide leukotriene levels did not reach statistical significance. In addition, eosinophil infiltration and endothelial nitric oxide synthase immunoreactivity in the nasal tissues were reduced in the Shu-Bi-Lin-treated group. Conclusions Shu-Bi-Lin could alleviate the nasal symptoms of AR, and its mechanism might be related to its inhibitory effect on type I anaphylaxis reactions and eosinophil infiltration in the nasal tissues, as well as the inhibition of some mediators related to AR. |
| Databáze: | OpenAIRE |
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