Non-traditional markers of atherosclerosis potentiate the risk of coronary heart disease in patients with type 2 diabetes and metabolic syndrome

Autor: Lucia Malloggi, M. Corfini, Giuseppe Penno, Stefano Del Prato, Graziano Di Cianni, Roberto Miccoli, M. G. Giovannitti, Rossana Barontini, Cristina Bianchi
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
Medicine (miscellaneous)
Coronary Disease
Type 2 diabetes
Risk Assessment
Gastroenterology
Risk Factors
Diabetes mellitus
Internal medicine
Odds Ratio
Prevalence
Humans
Medicine
education
National Cholesterol Education Program
Serum Albumin
Aged
Glycated Hemoglobin
Metabolic Syndrome
education.field_of_study
Nutrition and Dietetics
business.industry
Cholesterol
HDL
Fibrinogen
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Cholesterol
LDL
Odds ratio
Middle Aged
Atherosclerosis
medicine.disease
Uric Acid
Cholesterol
Cross-Sectional Studies
Endocrinology
Diabetes Mellitus
Type 2
Italy
Creatinine
Female
lipids (amino acids
peptides
and proteins)
Microalbuminuria
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
Biomarkers
Popis: Background and aims The aims of this study were to establish the prevalence of metabolic syndrome (MS), in type 2 diabetes mellitus (DM), according to National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, and to assess the association of MS with other cardiovascular (CV) risk factors in these patients. Methods and results A cross-sectional study was conducted in 1610 patients with type 2 DM. Glycated hemoglobin A1c (HbA1c), total cholesterol, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), uric acid, fibrinogen, creatinine, and albumin/creatinine ratios were measured. The risk of coronary heart disease (CHD) was calculated using the UKPDS Risk Engine. Seventy percent of the diabetic population met the criteria for MS; central obesity and hypertension were the most common criteria. Subjects with MS had higher levels of HbA1c, LDL-C, non-HDL-C, uric acid, and fibrinogen compared to patients without MS. Similarly, microalbuminuria and a high triglyceride (Tg)/HDL-C ratio (a marker of small LDL-C) occurred more frequently in patients with MS. When patients with no history of CHD events were considered, mean CHD risk was greater in those with, than those without, MS. Conclusions MS is highly prevalent in type 2 DM and is commonly associated with non-traditional CV risk factors. The diagnosis of MS seems to confer additional CHD risk in patients with type 2 diabetes.
Databáze: OpenAIRE
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