Streptococcus pyogenes preparation OK-432: immunoprophylactic and immunotherapeutic effects on the incidence of spontaneous leukemia in AKR mice
| Autor: | Tadao Aoki, Vincent W. Hollis, John P. Kvedar, Grace S. Bushar |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Cancer Research
Streptococcus pyogenes Immunoelectron microscopy Viremia medicine.disease_cause Antibodies Viral Virus Microbiology Mice Mice Inbred AKR Antigen Interferon medicine Animals Leukemia Experimental biology RNA-Directed DNA Polymerase medicine.disease Virology Leukemia Retroviridae Oncology biology.protein Female Immunization Immunotherapy Antibody medicine.drug |
| Zdroj: | Journal of the National Cancer Institute. 56(3) |
| ISSN: | 0027-8874 |
| Popis: | An inactivated and lyophilized preparation of a low virulence strain (Su) of Streptococcus pyogenes (group A) was designated OK-432. When 2- and 5-month-old AKR mice were inoculated im with OK-432 twice weekly throughout their life-spans, spontaneous leukemias occurred later and at a lower incidence than in control groups. By virus neutralization and cytotoxicity tests and by immunoelectron microscopy, antibodies against virus and cell-surface antigens of transplanted AKR leukemia were not detectable in sera of nonleukemic mice of any group. Whereas sera from mice treated with OK-432 were the only positive for interferon, viremia was clearly demonstrated in control groups by reverse transcriptase assays of the plasma. |
| Databáze: | OpenAIRE |
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