Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD)
| Autor: | Jos G.M. Hendriksen, Jelle Jolles, Frans J. M. Feron, Wim E.J. Weber, M. J. P. G. Van Kroonenburgh, Johan S.H. Vles |
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| Přispěvatelé: | RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: FPN NPPP I, Klinische Neurowetenschappen, Sociale Geneeskunde, Neuropsychology & Psychopharmacology, MUMC+: DA BV Medisch Specialisten Nucleaire Geneesk (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Dopamine Plasma Membrane Transport Proteins Down-Regulation Nerve Tissue Proteins Synaptic Transmission Receptors Dopamine Dopamine Internal medicine mental disorders medicine Humans Attention deficit hyperactivity disorder Child Dopamine transporter Tomography Emission-Computed Single-Photon Membrane Glycoproteins biology business.industry Methylphenidate Dopaminergic Neuropsychology Membrane Transport Proteins General Medicine medicine.disease Treatment Outcome Endocrinology Attention Deficit Disorder with Hyperactivity Dopamine receptor Pediatrics Perinatology and Child Health biology.protein Central Nervous System Stimulants Neurology (clinical) business Neuroscience Follow-Up Studies Signal Transduction medicine.drug |
| Zdroj: | Neuropediatrics, 34(2), 77-80. Georg Thieme Verlag |
| ISSN: | 1439-1899 0174-304X |
| Popis: | Methylphenidate down-regulates the dopamine receptor and transporter system in children with attention deficit hyperkinetic disorder (ADHD).Vles JS, Feron FJ, Hendriksen JG, Jolles J, van Kroonenburgh MJ, Weber WE.Department of Child Neurology, University Hospital Maastricht, Maastricht, The Netherlands. jvle@sneu.azm.nlAdults suffering from Attention Deficit Hyperactivity Disorder (ADHD) are known to have disturbed central dopaminergic transmission. With Single Photon Emission Computed Tomography (SPECT) we studied brain dopamine transporter and receptor activity in six boys with ADHD. Three months after initiation of treatment with methylphenidate we found a down-regulation of the post-synaptic dopamine receptor with a maximum of 20 % and a down-regulation of the dopamine transporter with a maximum of 74.7 % in the striatal system. This corresponded to a positive clinical response evaluated by neuropsychological questionnaires and tests. We suggest that dopamine transporter imaging by SPECT might be used to monitor psychostimulant treatment in children suffering from ADHD |
| Databáze: | OpenAIRE |
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