| Autor: |
I. Yu. Pikhteleva, V. S. Romanova, O. V. Dobrokhotova, D. V. Mishchenko, R. A. Kotel’nikova, L. V. Tat’yanenko, G. N. Bogdanov, Alexander I. Kotelnikov, D. A. Poletayeva |
| Předmět: |
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| Zdroj: |
ResearcherID |
| Popis: |
The effect of nitroxyalkyl derivatives of fullerenylproline methyl ester on the enzymatic activity of Ca2+-ATPase of sarcoplasmic reticulum (SR) has been studied. It is shown that hybrid derivatives of C60 fullerene are capable of inhibiting the activity of Ca2+-ATPase of SR. The mononitrate inhibits the hydrolytic activity of the enzyme with K i = 1.92 × 10−6 M; active Ca2+ transport, with K i = 3.79 × 10−6 M. The dinitrate inhibits ATP hydrolysis with K i = 2.38 × 10−8 M; Ca2+ transport, with K i = 3.08 × 10−8 M. Fullerenylproline methyl ester does not affect the enzymatic activity of Ca2+-ATPase. Based on these data it is possible to predict the possible fields of application for hybrid fullerene derivatives as potential drugs. |
| Databáze: |
OpenAIRE |
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