Attenuated amplitude of circadian and sleep-dependent modulation of electroencephalographic sleep spindle characteristics in elderly human subjects
Autor: | Henry G Wei, Derk-Jan Dijk, Eymard Riel, Charles A. Czeisler |
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Rok vydání: | 1999 |
Předmět: |
Adult
Male medicine.medical_specialty medicine.diagnostic_test General Neuroscience Age Factors Eye movement Sleep spindle Electroencephalography Non-rapid eye movement sleep Sleep in non-human animals Body Temperature Circadian Rhythm Electrophysiology Endocrinology Internal medicine medicine Humans Female Circadian rhythm Psychology Sleep Slow-wave sleep Aged |
Zdroj: | Neuroscience letters. 260(1) |
ISSN: | 0304-3940 |
Popis: | Sleep spindles are 12-15 Hz electroencephalographic (EEG) oscillations characteristic of non-rapid eye movement (non-REM) sleep. Sleep EEG recordings (total 252 episodes; duration, 9 h 20 min each) distributed across the circadian cycle were analyzed in eight young and eight elderly human subjects. In the young subjects, sleep spindle amplitude, frequency, duration and incidence displayed significant circadian modulation, with the highest spindle incidence and amplitude and the lowest spindle frequency coincident with circadian phases associated with times of habitual sleep. In the elderly subjects, overall amplitude, duration, and incidence were reduced, and only spindle frequency exhibited a detectable circadian modulation. The results demonstrate that a circadian process modulates sleep spindle characteristics and that the strength of this circadian modulation is reduced with age. |
Databáze: | OpenAIRE |
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