Unique Novel Role of Adropin in a Gastric Ulcer in a Rotenone-Induced Rat Model of Parkinson’s Disease
| Autor: | Ghada A. Badawi, Heba M. Arakeep, Rehab E. Abo El Gheit, Marwa N. Emam, Marwa Mohamed Atef, Hanan AlSaeid Alshenawy, Omnia S. El Deeb, Walaa M. Elwan |
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| Rok vydání: | 2020 |
| Předmět: |
Vascular Endothelial Growth Factor A
Parkinson's disease Physiology Cognitive Neuroscience Rat model Disease Pharmacology Biochemistry Neuroprotection Mice Phosphatidylinositol 3-Kinases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dopamine Rotenone Animals Medicine Stomach Ulcer 030304 developmental biology 0303 health sciences business.industry Gastric H+/K+ ATPase Neurodegenerative Diseases Parkinson Disease Cell Biology General Medicine medicine.disease digestive system diseases Rats Oxidative Stress Neuroprotective Agents chemistry business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | ACS Chemical Neuroscience. 11:3077-3088 |
| ISSN: | 1948-7193 |
| Popis: | Parkinson's disease (PD) is the second most common neurodegenerative disease, frequently associated with a gastric ulcer. We aimed to investigate the adropin neuroprotective/gastroprotective potential in the indomethacin (IND)-induced gastric ulcer in a rotenone-induced PD model. Rats were randomly divided into four groups: normal control group, rotenone/IND treated (PD /Ulcer) group, adropin treated PD/Ulcer group, and l-dopa/omeprazole (Om) treated PD/Ulcer group. There were ten rats selected for the normal control group. Striatal dopamine (DA), apoptosis/redox status, and motor/behavioral impairments were evaluated. Gastric oxidative stress, H |
| Databáze: | OpenAIRE |
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