Aggressive Locoregional Surgical Therapy for Gastric Peritoneal Carcinomatosis
| Autor: | Haroon A. Choudry, Matthew P. Holtzman, Steven A. Ahrendt, David L. Bartlett, Heather Jones, Herbert J. Zeh, Joshua Winer, Arun Mavanur, Deepa Magge, Amer H. Zureikat, Kenneth K.W. Lee, Mazen S. Zenati, Lekshmi Ramalingam, James F. Pingpank |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Gastroenterology Article Gastrectomy Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Prospective Studies Prospective cohort study Lymph node Survival rate Peritoneal Neoplasms Survival analysis Neoplasm Staging business.industry Proportional hazards model Hazard ratio Hyperthermia Induced Middle Aged Prognosis Combined Modality Therapy Surgery Survival Rate medicine.anatomical_structure Oncology Chemotherapy Cancer Regional Perfusion Peritoneal Cancer Index Female business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 21:1448-1455 |
| ISSN: | 1534-4681 1068-9265 |
| Popis: | Background. Peritoneal carcinomatosis from gastric cancer (GPC) responds poorly to systemic chemotherapy. Limited published data demonstrate improved outcomes after aggressive locoregional therapies. We assessed the efficacy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) in GPC. Methods. We prospectively analyzed 23 patients with GPC undergoing CRS/HIPEC between 2001 and 2010. Kaplan–Meier survival curves and multivariate Cox regression models identified prognostic factors affecting oncologic outcomes. Results. CRS/HIPEC was performed for synchronous GPC in 20 patients and metachronous GPC in 3 patients. Adequate CRS was achieved in 22 patients (CC-0 = 17; CC-1 = 5) and median peritoneal cancer index was 10.5. Most patients received preoperative chemotherapy (83 %) and total gastrectomy (78 %). Pathology revealed diffuse histology (65 %), signet cells (65 %) and LN involvement (64 %). Major postoperative morbidity occurred in 12 patients, with 1 in-hospital mortality at postoperative day 66. With median follow-up of 52 months, median overall survival (OS) was 9.5 months (95 % confidence interval 4.7–17.3), with 1- and 3- year OS rates of 50 and 18 %. Median progression-free survival (PFS) was 6.8 months (95 % confidence interval 3.9–14.6). In a multivariate Cox regression model, male gender [hazard ratio (HR) 6.3], LN involvement (HR 1.2), residual tumor nodules (HR 2.4), and [2 anastomoses (HR 2.8) were joint significant predictors of poor OS (v 2 = 18.2, p = 0.001), while signet cells (HR 8.9), anastomoses[2 (HR 5.5), and male gender (HR 2.4) were joint significant predictors of poor progression (v 2 = 16.3, p = 0.001). Conclusions. Aggressive CRS/HIPEC for GPC may confer a survival benefit in select patients with limited lymph node involvement and completely resectable disease requiring less extensive visceral resections. |
| Databáze: | OpenAIRE |
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