The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon

Autor:	Stephen J. Keely, Magdalena S. Mroz, Joseph B. J. Ward
Rok vydání:	2013
Předmět:	medicine.medical_specialty Colon Physiology medicine.drug_class Biology Receptors G-Protein-Coupled Bile Acids and Salts chemistry.chemical_compound Basal (phylogenetics) Organ Culture Techniques Internal medicine medicine Animals Cholinergic neuron Receptor Bile acid Endocrine and Autonomic Systems Gastroenterology Cholic acid Cholic Acids Epithelial Cells G protein-coupled bile acid receptor Cholinergic Neurons Rats Endocrinology chemistry Enterochromaffin cell Cholinergic
Zdroj:	Neurogastroenterology & Motility. 25:708-711
ISSN:	1350-1925
DOI:	10.1111/nmo.12148
Popis:	Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been recently shown to be expressed on enteric nerves and enterochromaffin cells (ECs), where its activation regulates small intestinal and colonic motility. Here, we show that TGR5 is also expressed on colonic epithelial cells and that its activation decreases basal secretory tone and inhibits cholinergic-induced secretory responses. Our data demonstrate a new role for TGR5 in regulating colonic fluid and electrolyte transport and suggest that the receptor represents a good therapeutic target for intestinal transport disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753c4216e2ee41c1ca6697540784e194 https://doi.org/10.1111/nmo.12148 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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