The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development
| Autor: | Jody A. Summers, Angelica R. Harper |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
genetic structures Glaucoma Eye Refraction Ocular Article Extracellular matrix Cellular and Molecular Neuroscience Ophthalmology Extracellular medicine Myopia Animals Humans business.industry Retinal detachment Macular degeneration medicine.disease Sensory Systems eye diseases Sclera Biomechanical Phenomena Extracellular Matrix medicine.anatomical_structure sense organs business |
| Zdroj: | Experimental eye research. 133 |
| ISSN: | 1096-0007 |
| Popis: | Myopia is a common ocular condition, characterized by excessive elongation of the ocular globe. The prevalence of myopia continues to increase, particularly among highly educated groups, now exceeding 80% in some groups. In parallel with the increased prevalence of myopia, are increases in associated blinding ocular conditions including glaucoma, retinal detachment and macular degeneration, making myopia a significant global health concern. The elongation of the eye is closely related to the biomechanical properties of the sclera, which in turn are largely dependent on the composition of the scleral extracellular matrix. Therefore an understanding of the cellular and extracellular events involved in the regulation of scleral growth and remodeling during childhood and young adulthood will provide future avenues for the treatment of myopia and its associated ocular complications. |
| Databáze: | OpenAIRE |
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