Characterization of resident and migratory dendritic cells in human lymph nodes

Autor: Xavier Sastre-Garau, Elodie Segura, Marie-Hélène Donnadieu, Sebastian Amigorena, Jenny Valladeau-Guilemond, Vassili Soumelis
Přispěvatelé: Immunité et cancer (U932), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Curie-Université Paris Descartes - Paris 5 (UPD5), Centre de Recherche en Cancérologie de Lyon (CRCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Biologie des Tumeurs, Institut Curie, Immunité et cancer ( U932 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Recherche en Cancérologie de Lyon ( CRCL ), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), INSTITUT CURIE, Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
MESH: Antigens
CD1
Lipopolysaccharide Receptors
MESH : Receptors
Cell Surface
MESH: Lymph Nodes
[ SDV.CAN ] Life Sciences [q-bio]/Cancer
Antigens
CD1
0302 clinical medicine
Cell Movement
MESH : Lectins
C-Type
Immunology and Allergy
MESH : Cell Movement
MESH: Cell Movement
MESH : Lymph Nodes
MESH : Mannose-Binding Lectins
Skin
MESH: Receptors
Cell Surface
0303 health sciences
integumentary system
MESH: Dendritic Cells
MESH: Antigens
CD14
Cell Polarity
hemic and immune systems
3. Good health
medicine.anatomical_structure
Lymph
MESH: Cell Polarity
MESH : Cell Polarity
Mannose Receptor
T cell
Immunology
Spleen
Receptors
Cell Surface
chemical and pharmacologic phenomena
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
03 medical and health sciences
Immune system
Th2 Cells
Antigen
MESH: Skin
MESH: Th2 Cells
MESH: Mannose-Binding Lectins
medicine
MESH : Skin
Humans
Lectins
C-Type
030304 developmental biology
MESH: Humans
MESH : Humans
Brief Definitive Report
Dendritic Cells
In vitro
MESH : Th2 Cells
MESH : Antigens
CD14
Mannose-Binding Lectins
MESH : Antigens
CD1
Tonsil
MESH : Dendritic Cells
Lymph Nodes
CD8
MESH: Lectins
C-Type
030215 immunology
Zdroj: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2012, 209 (4), pp.653-60. ⟨10.1084/jem.20111457⟩
Journal of Experimental Medicine, Rockefeller University Press, 2012, 209 (4), pp.653-60. 〈10.1084/jem.20111457〉
The Journal of Experimental Medicine
ISSN: 0022-1007
1540-9538
DOI: 10.1084/jem.20111457⟩
Popis: Human skin-draining lymph nodes contain functionally distinct subsets of resident and migratory dendritic cells.
Dendritic cells (DCs) initiate adaptive immune responses in lymph nodes (LNs). In mice, LN DCs can be divided into resident and tissue-derived populations, the latter of which migrate from the peripheral tissues. In humans, different subsets of DCs have been identified in the blood, spleen, and skin, but less is known about populations of resident and migratory tissue-derived DCs in LNs. We have analyzed DCs in human LNs and identified two populations of resident DCs that are present in all LNs analyzed, as well as in the spleen and tonsil, and correspond to the two known blood DC subtypes. We also identify three main populations of skin-derived migratory DCs that are present only in skin-draining LNs and correspond to the DC subsets found in the skin. Resident DCs subsets induce both Th1 and Th2 cytokines in naive allogeneic T lymphocytes, whereas the corresponding blood subsets failed to induce efficient Th2 polarization. LN-resident DCs also cross-present antigen without in vitro activation, whereas blood DCs fail to do so. Among migratory DCs, one subset was poor at both CD4+ and CD8+ T cell activation, whereas the other subsets induced only Th2 polarization. We conclude that in humans, skin-draining LNs host both resident and migratory DC subsets with distinct functional abilities.
Databáze: OpenAIRE
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