Impact of high risk thrombophilia status on recurrence among children and adults with VTE: An observational multicenter cohort study
| Autor: | Ralf Knoefler, Gloria Brüwer, Maria Shneyder, Karin Kurnik, Christine Heller, Susanne Holzhauer, Karim Kentouche, Daniela Manner, Verena Limperger, Ulrich Finckh, Ralf Junker, Melchior Lauten, Frauke Degenhardt, Gili Kenet, Rolf M. Mesters, Anne Krümpel, Ulrich C. Klostermeier, Ulrike Nowak-Göttl, Ralf Ulrich Trappe |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Protein S Deficiency Adolescent 030204 cardiovascular system & hematology Thrombophilia Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Recurrence Risk Factors Protein C deficiency Humans Medicine cardiovascular diseases Protein S deficiency Young adult Risk factor Child Medical History Taking Molecular Biology business.industry Age Factors Absolute risk reduction Protein C Deficiency Venous Thromboembolism Cell Biology Hematology Middle Aged medicine.disease Pulmonary embolism Child Preschool Molecular Medicine business 030215 immunology Cohort study |
| Zdroj: | Blood Cells, Molecules, and Diseases. 62:24-31 |
| ISSN: | 1079-9796 |
| Popis: | Background: Antithrombin [AT]-, protein C [PC]- or protein S [PS]-deficiency [D] constitutes a major risk factor for venous thromboembolism [VIE]. Primary study objective was to evaluate if the clinical presentation at first VTE onset differs between children and adults and to compare the individual recurrence risk among patients with respect to age at onset and their thrombophilia status ATD, PCD or PSD. Methods/Patients/Results: In 137 of 688 consecutively enrolled pediatric and adult VTE patients we calculated the absolute risk of VTE recurrence and event-free-survival adjusted for thrombophilia and positive family VTE history. At first VTE children manifested i) with a lower rate of pulmonary embolism, ii) a higher rate of cerebral vascular events or multiple VIES, and showed a higher proportion of unprovoked VIE compared to adolescents and adults. Adult patients reported more often a positive VIE history compared to younger study participants. The adjusted odds of recurrence in adults was 2.05 compared to children. Conclusion: At disease manifestation children and adults differ with respect to i) thrombotic locations, ii) percentage of unprovoked versus provoked VIE, and iii) different rates of positive VTE family histories. Furthermore, adults showed a two-fold increase risk of VTE recurrence compared to children. (C) 2016 ELSEVIER. All rights reserved. |
| Databáze: | OpenAIRE |
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