PHF2, a novel PHD finger gene located on human chromosome 9q22
| Autor: | Thomas Theil, Brian P. Chadwick, Anna-Marie Frischauf, Stephanie Kate Heath, Kerstin Hasenpusch-Theil, David G. Wilkinson |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Candidate gene DNA Complementary Molecular Sequence Data Nuclear Localization Signals In situ hybridization Biology Mice Genetics Animals Humans Amino Acid Sequence Cloning Molecular Gene Synteny Cloning Homeodomain Proteins Sequence Homology Amino Acid Chromosome Chromosome Mapping Proteins Cell biology PHD finger Chromosomes Human Pair 9 Nuclear localization sequence |
| Zdroj: | Mammalian genome : official journal of the International Mammalian Genome Society. 10(3) |
| ISSN: | 0938-8990 |
| Popis: | We have isolated and characterized a novel PHD finger gene, PHF2, which maps to human Chromosome (Chr) 9q22 close to D9S196. Its mouse homolog was also characterized and mapped to the syntenic region on mouse Chr 13. The predicted human and mouse proteins are 98% identical and contain a PHD finger domain, eight possible nuclear localization signals, two potential PEST sequences, and a novel conserved hydrophobic domain. Northern analysis shows widespread expression of PHF2 in adult tissues, while in situ hybridization on mouse embryos reveals staining in the neural tube and dorsal root ganglia significantly above a ubiquitous low level expression signal. From its expression pattern and its chromosomal localization, PHF2 is a candidate gene for hereditary sensory neuropathy type I, HSN1. |
| Databáze: | OpenAIRE |
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