Effect of Phenobarbital on Nitric Oxide Level in Term Newborn Infants with Perinatal Asphyxia
| Autor: | Roya Reisi, Hajar Noormohammadi, Soleiman Kheiri, Abolfazl Khoshdel, Gholam Reza Panahandeh, Esfandiar Heidarian, Seyed Mohammad-Kazem Nourbakhsh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Central nervous system
Encephalopathy lcsh:Medicine Nitric Oxide Nitric oxide chemistry.chemical_compound Asphyxia medicine medicine.diagnostic_test business.industry Incidence (epidemiology) lcsh:R Magnetic resonance imaging Electroencephalography General Medicine medicine.disease Magnetic Resonance Imaging Perinatal asphyxia medicine.anatomical_structure chemistry Anesthesia Phenobarbital Original Article medicine.symptom business medicine.drug |
| Zdroj: | Oman Medical Journal, Vol 31, Iss 5, Pp 332-335 (2016) |
| ISSN: | 2070-5204 |
| Popis: | Objectives: Perinatal asphyxia (PA) is very significant in perinatal medicine due to the involvement of the central nervous system. This study was conducted to investigate the biochemical, clinical, and paraclinical changes associated with phenobarbital administration in neonates with PA. Methods: In this prospective, case-control study, 30 neonates with PA in two groups of 15 each (case and control) were investigated. The case group received 20 mg/kg intravenous phenobarbital within six hours of birth, and the control group did not receive phenobarbital. Serum concentrations of nitric oxide (NO) were measured at enrollment and one week after birth in the two groups. Clinical, electroencephalography, and magnetic resonance imaging findings of the two groups were compared. Results: At enrollment, the two groups did not differ in clinical severity, seizure incidence, or NO concentration. After one week, NO concentration was significantly lower in the case group (p < 0.050), but there was no significant difference in other variables between the two groups. Conclusions: Early administration of phenobarbital in term neonates with PA could protect them against encephalopathy. |
| Databáze: | OpenAIRE |
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