SMYD proteins in immunity: dawning of a new era
| Autor: | Chunying Li, Zhe Yang, Maysaa Doughan, Nicholas Spellmon |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Protein family
Biophysics Biology medicine.disease_cause Biochemistry Article 03 medical and health sciences 0302 clinical medicine Structural Biology Immunity medicine lcsh:QH301-705.5 Molecular Biology Gene 030304 developmental biology 0303 health sciences Oncogene Cardiac muscle Cancer medicine.disease 3. Good health medicine.anatomical_structure lcsh:Biology (General) 030220 oncology & carcinogenesis Immunology Cancer research Cancer development Carcinogenesis |
| Zdroj: | AIMS biophysics AIMS Biophysics, Vol 3, Iss 4, Pp 450-455 (2016) |
| ISSN: | 2377-9098 |
| DOI: | 10.3934/biophy.2016.4.450 |
| Popis: | In the past decade, the SMYD protein family has gradually become a center of research, thanking for its essential role in heart and muscle development and cancer development. However, because of such a role, the research scope for the SMYD protein family has been fairly stereotyped, its focus largely restricted to muscle and cancer. Initial studies of SMYD1 and SMYD3 were responsible for these biased research directions. SMYD1 was originally identified as a myogenic factor and regulated cardiomyocyte maturation and proper formation of the right ventricle [1]. SMYD3 was initially identified as an oncogene and regulated expression of cell-cycle genes in colorectal and hepatocellular carcinomas [2]. These findings have clearly indicated an essential role of SMYD1 and SMYD3 in cardiac muscle development and tumorigenesis respectively. Because of this, the research directions in SMYD proteins have been strongly influenced by these two studies, and much subsequent research has biased towards muscle and cancer. |
| Databáze: | OpenAIRE |
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