Computational analysis reveals increased blood deposition following repeated mild traumatic brain injury
| Autor: | Monica J. Carson, Anthony Bianchi, Andre Obenaus, Bir Bhanu, Virginia Donovan, Richard E. Hartman |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
computer.software_genre 0302 clinical medicine Injury - Trauma - (Head and Spine) Voxel Cortex (anatomy) Edema 2.1 Biological and endogenous factors Computational analysis FA fractional anisotropy Aetiology 0303 health sciences T2 medicine.diagnostic_test diffusion tensor imaging Hemorrhagic progression medicine.anatomical_structure Neurology DTI HPC Neurological mean diffusivity Biomedical Imaging medicine.symptom fractional anisotropy medicine.medical_specialty FA Traumatic brain injury Cognitive Neuroscience HPC hemorrhagic progression of the contusion Neuropathology Article Lesion 03 medical and health sciences medicine Radiology Nuclear Medicine and imaging Quantitative magnetic resonance imaging 030304 developmental biology MD mean diffusivity Histogram business.industry MD Neurosciences Magnetic resonance imaging medicine.disease Brain Disorders hemorrhagic progression of the contusion Injury (total) Accidents/Adverse Effects Neurology (clinical) DTI diffusion tensor imaging business Injury - Traumatic brain injury computer 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage. Clinical, vol 1, iss 1 NeuroImage : Clinical |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2012.08.001 |
| Popis: | Mild traumatic brain injury (mTBI) has become an increasing public health concern as subsequent injuries can exacerbate existing neuropathology and result in neurological deficits. This study investigated the temporal development of cortical lesions using magnetic resonance imaging (MRI) to assess two mTBIs delivered to opposite cortical hemispheres. The controlled cortical impact model was used to produce an initial mTBI on the right cortex followed by a second injury induced on the left cortex at 3 (rmTBI 3d) or 7 (rmTBI 7d) days later. Histogram analysis was combined with a novel semi-automated computational approach to perform a voxel-wise examination of extravascular blood and edema volumes within the lesion. Examination of lesion volume 1d post last injury revealed increased tissue abnormalities within rmTBI 7d animals compared to other groups, particularly at the site of the second impact. Histogram analysis of lesion T2 values suggested increased edematous tissue within the rmTBI 3d group and elevated blood deposition in the rm TBI 7d animals. Further quantification of lesion composition for blood and edema containing voxels supported our histogram findings, with increased edema at the site of second impact in rmTBI 3d animals and elevated blood deposition in the rmTBI 7d group at the site of the first injury. Histological measurements revealed spatial overlap of regions containing blood deposition and microglial activation within the cortices of all animals. In conclusion, our findings suggest that there is a window of tissue vulnerability where a second distant mTBI, induced 7d after an initial injury, exacerbates tissue abnormalities consistent with hemorrhagic progression. Highlights ► rmTBI 7d apart resulted in an increased total lesion volume 1d post last injury. ► Lesion volume was increased at the distant second injury site in rmTBI 7d animals. ► Increased edema was seen at the distant second injury site in rmTBI 3d animals. ► Voxel-wise analysis detected hemorrhagic progression in rmTBI 7d animals. ► Increased microglia were observed in the rmTBI 7d animals. |
| Databáze: | OpenAIRE |
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