Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma
Autor: | Markus Stücker, Eggert Stockfleth, Jörg Schaller, H.-J. Schulze, Thilo Gambichler, I. Hartenstein, M. Dreißigacker, Kerstin Lang, Jürgen C. Becker, Thomas Brüning, Heiko U. Käfferlein |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Patched Skin Neoplasms animal structures Medizin Dermatology Biology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Trichoepithelioma medicine Humans Hedgehog Proteins Basal cell carcinoma Hedgehog Microcystic adnexal carcinoma Aged Aged 80 and over Middle Aged medicine.disease Immunohistochemistry PTCH1 Head and Neck Neoplasms 030220 oncology & carcinogenesis Cancer research Female Neoplasms Adnexal and Skin Appendage Facial Neoplasms Smoothened Signal Transduction |
Zdroj: | Clinical and Experimental Dermatology. 46:1052-1057 |
ISSN: | 1365-2230 0307-6938 |
DOI: | 10.1111/ced.14634 |
Popis: | Background Microcystic adnexal carcinoma (MAC) is a rare skin neoplasm that has not been characterized on a molecular basis. Objectives We aimed to assess expression profiles of hedgehog (HH) signaling molecules in MAC and control tumours. Methods Immunohistochemistry was performed for Sonic HH (SHH), Indian HH (IHH), Patched 1 (PTCH1), and Smoothened (SMO) on patients' MAC (n=26) tissue and control tumour tissue, including syringoma (SyG; n=11), trichoepithelioma (TE; n=11), and basal cell carcinoma (BCC; n=12). Results PTCH1 and SMO immunoreactivity was significantly higher in BCC than in SyG, TE, and MAC (P = 0.000002 and P = 0.029, respectively). The highest IHH expression was observed in BCC and TE when compared to SyG and MAC (P = 0.038). Notably, the highest SHH protein expression was observed in SyG as compared to MAC, TE, and even BCC (P = 0.00075). In MAC patients, SMO immunoreactivity significantly (r = 0.51; P = 0.0086) correlated with PTCH1 expression. Further correlation studies did not show significant associations between the HH expression markers assessed (P > 0.05). Conclusions Our results indicate that alterations of the HH signaling are unlikely to play a major role in the pathogenesis of MAC, which is in contrast to the morphologically similar BCC and TE. Our observation provides additional information to the limited molecular pathology knowledge on this rare tumour. |
Databáze: | OpenAIRE |
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