Hepatocellular carcinoma treated by percutaneous hot saline injection
| Autor: | Utako Yoshioka, Yoshihide Hujiyama, Mitsuyo Urabe, Tadao Bamba, Miya Hukano, Hisayuki Inoue, Yoshio Araki, Tomoyuki Tsujikawa |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Abdominal pain Carcinoma Hepatocellular Time Factors Percutaneous medicine.medical_treatment Injections Intralesional Sodium Chloride Body Temperature Carcinoma medicine Humans Saline Aged Skin Ultrasonography Fibrous capsule of Glisson business.industry Liver Neoplasms Temperature General Medicine Middle Aged medicine.disease Treatment Outcome Liver Oncology Hepatocellular carcinoma Toxicity Female Radiology medicine.symptom Percutaneous ethanol injection Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | Oncology Reports. |
| ISSN: | 1791-2431 1021-335X |
| Popis: | Percutaneous ethanol injection therapy (PEI) is one of the local methods widely used for hepatocellular carcinoma (HCC) ablation. However, this method is limited by the toxicity of ethanol and severe pain derived from irritation of the peritoneum of the liver capsule. Therefore, we have focused on the heat coagulation necrosis effect of boiled hot saline and devised percutaneous hot water injection therapy (PHoT) as a new local treatment method. PHoT was performed in 17 patients with HCC (total 24 nodules: 11 nodules2 cm in diameter, 10 nodules from 2-4 cm, and 3 nodules4 cm). Changes in the AFP values, and both CT and ultrasonography (US) findings before and after treatment were investigated. All 24 tumors received 1 or more treatments (average, 3.3 treat-ments) of PHoT. The injection volume ranged from 3-26 ml (average, 11.2 ml). The total volume of the injection per tumor ranged from 10-37.2 ml (average, 37.2 ml). The AFP values decreased in all patients who initially showed high values. On CT scanning, all lesions receiving PHoT became hypodense. The disappearance of the tumor was also confirmed by contrast-enhanced CT. No severe complications, excluding mild abdominal pain and skin burning, were observed during the procedure. In conclusion, PHoT shows good anti-tumor effects despite a small number of punctures and holds promise as a curative local treatment method for small HCCs. |
| Databáze: | OpenAIRE |
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