Extracellular matrix biomarker, fibulin-1 and its association with soluble uPAR in a bi-ethnic South African population: the SAfrEIC study

Autor: Lars Melholt Rasmussen, Jesper Eugen-Olsen, Christine Susara du Plooy, Hugo W. Huisman, Aletta E. Schutte, Ruan Kruger
Přispěvatelé: 21247366 - Du Plooy, Christine Susara, 10062718 - Huisman, Hugo Willem, 20035632 - Kruger, Ruan, 10922180 - Schutte, Aletta Elisabeth
Rok vydání: 2014
Předmět:
Pulmonary and Respiratory Medicine
Adult
Male
medicine.medical_specialty
Atherosclerosis/blood
Cardiac fibrosis
European Continental Ancestry Group
Black People
Inflammation
Caucasian
Calcium-Binding Proteins/blood
White People
Receptors
Urokinase Plasminogen Activator
Serum Albumin/metabolism
South Africa
Internal medicine
medicine
Humans
African Cardiac fibrosis Caucasian Fibulin-1 Inflammation Soluble Urokinase-Type Plasminogen Activator Receptor PLASMINOGEN-ACTIVATOR RECEPTOR C-REACTIVE PROTEIN CARDIOVASCULAR-DISEASE ARTERIAL STIFFNESS VASCULAR INFLAMMATION HEART-DISEASE PATHOGENESIS EXPRESSION MORTALITY ESTROGEN
Serum Albumin
Receptors
Urokinase Plasminogen Activator/blood
African Continental Ancestry Group
business.industry
Fibulin-1
C-Reactive Protein/metabolism
South Africa/ethnology
African
Calcium-Binding Proteins
Albumin
Middle Aged
medicine.disease
Atherosclerosis
Fibulin
Urokinase receptor
Endocrinology
C-Reactive Protein
SuPAR
Soluble Urokinase-Type Plasminogen Activator Receptor
Biomarker (medicine)
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Plasminogen activator
Biomarkers/blood
Biomarkers
Zdroj: du Plooy, C S, Kruger, R, Huisman, H W, Rasmussen, L M, Eugen-Olsen, J & Schutte, A E 2015, ' Extracellular Matrix Biomarker, Fibulin-1 and Its Association with Soluble uPAR in a Bi-ethnic South African Population : The SAfrEIC Study ', Heart, Lung and Circulation
, vol. 24, no. 3, pp. 298-305 . https://doi.org/10.1016/j.hlc.2014.09.019
ISSN: 1444-2892
DOI: 10.1016/j.hlc.2014.09.019
Popis: Background: Fibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate inflammatory processes associated with extracellular matrix turnover in atherosclerosis. We explored the independent relationship of fibulin-1 with these inflammatory markers in a bi-ethnic South African population. Methods: This study included 290 Africans (men: n. =. 130 and women: n. =. 160) and 343 sex- and age-matched Caucasians (men: n. =. 160 and women: n. =. 183). Serum fibulin-1, suPAR, CRP and albumin levels were measured along with conventional cardiovascular and metabolic variables. Results: In both single and age-adjusted regression analyses, fibulin-1 correlated with both suPAR and albumin in African men and with suPAR in Caucasian men. These findings were absent in women. In multivariate regression analysis, these associations were confirmed in African men (R 2=0.22; β=0.329; p2=0.14; β=0.234; p=0.008). Fibulin-1 independently associated positively with suPAR in all men, but inversely with albumin in African men only. Conclusions: These results are indicating the presence of potential subclinical inflammation (suPAR) within the extracellular matrix of endothelial tissue, contributing to the potential onset of cardiac fibrosis or vascular sclerosis among these South African men with lower albumin levels.
Databáze: OpenAIRE
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